Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 114987..115413 | Replicon | plasmid pOQX_J9_2 |
| Accession | NZ_CP075063 | ||
| Organism | Escherichia coli strain EC_J_9 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | H4F96_RS24420 | Protein ID | WP_001372321.1 |
| Coordinates | 114987..115112 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 115189..115413 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H4F96_RS24390 (110361) | 110361..111050 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| H4F96_RS24395 (111237) | 111237..111620 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| H4F96_RS24400 (111941) | 111941..112543 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| H4F96_RS24405 (112840) | 112840..113661 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| H4F96_RS24410 (113779) | 113779..114066 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| H4F96_RS25865 (114091) | 114091..114297 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| H4F96_RS25870 (114367) | 114367..114539 | + | 173 | Protein_125 | hypothetical protein | - |
| H4F96_RS24415 (114537) | 114537..114767 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| H4F96_RS24420 (114987) | 114987..115112 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| H4F96_RS25875 (115054) | 115054..115203 | - | 150 | Protein_128 | plasmid maintenance protein Mok | - |
| - (115189) | 115189..115413 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (115189) | 115189..115413 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (115189) | 115189..115413 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (115189) | 115189..115413 | - | 225 | NuclAT_0 | - | Antitoxin |
| H4F96_RS24425 (115225) | 115225..115413 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| H4F96_RS24430 (115382) | 115382..116144 | - | 763 | Protein_130 | plasmid SOS inhibition protein A | - |
| H4F96_RS24435 (116141) | 116141..116575 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| H4F96_RS24440 (116630) | 116630..116827 | - | 198 | Protein_132 | hypothetical protein | - |
| H4F96_RS24445 (116855) | 116855..117088 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| H4F96_RS24450 (117156) | 117156..117695 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| H4F96_RS24455 (117721) | 117721..117927 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| H4F96_RS25880 (117997) | 117997..118077 | + | 81 | Protein_136 | hypothetical protein | - |
| H4F96_RS25885 (118260) | 118260..118429 | - | 170 | Protein_137 | hypothetical protein | - |
| H4F96_RS24460 (119023) | 119023..119994 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | oqxA / oqxB / aph(3')-Ia / sitABCD | iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA | 1..140375 | 140375 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T202791 WP_001372321.1 NZ_CP075063:c115112-114987 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T202791 NZ_CP099610:c2244842-2244549 [Pseudomonas moraviensis]
ATGACTTATCTTATCCAGCAAACCGCAATATTCCACGCTTGGCACCGTTCGATTAGAGACTTGCGCGCCAAAGTGGCTAT
CGCCCGGCGTATTGATCGGGCGTCAACAGGTAATCTCGGCGACGCCAAATCGGTGGGCGATGGAGTCTCTGAGATGCGTC
TGGATGTTGGCGCGGGCTACCGGGTGTATTTCACAATCCGCAATGGCGCAGTAATCATTCTGCTTGCCGGAGGCGACAAA
TCCTCACAAAGCGCAGACATCCGACGCGCACAAAAAATGGCAAAGGAGGTTTAA
ATGACTTATCTTATCCAGCAAACCGCAATATTCCACGCTTGGCACCGTTCGATTAGAGACTTGCGCGCCAAAGTGGCTAT
CGCCCGGCGTATTGATCGGGCGTCAACAGGTAATCTCGGCGACGCCAAATCGGTGGGCGATGGAGTCTCTGAGATGCGTC
TGGATGTTGGCGCGGGCTACCGGGTGTATTTCACAATCCGCAATGGCGCAGTAATCATTCTGCTTGCCGGAGGCGACAAA
TCCTCACAAAGCGCAGACATCCGACGCGCACAAAAAATGGCAAAGGAGGTTTAA
Antitoxin
Download Length: 225 bp
>AT202791 NZ_CP075063:c115413-115189 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
