Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1904006..1904508 | Replicon | chromosome |
| Accession | NZ_CP075062 | ||
| Organism | Escherichia coli strain EC_J_9 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | H4F96_RS09150 | Protein ID | WP_000767829.1 |
| Coordinates | 1904254..1904508 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | H4F96_RS09145 | Protein ID | WP_001259255.1 |
| Coordinates | 1904006..1904257 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H4F96_RS09120 (1899184) | 1899184..1900251 | - | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| H4F96_RS09125 (1900251) | 1900251..1901321 | - | 1071 | WP_000108950.1 | histidinol-phosphate transaminase | - |
| H4F96_RS09130 (1901318) | 1901318..1902622 | - | 1305 | WP_001499066.1 | histidinol dehydrogenase | - |
| H4F96_RS09135 (1902628) | 1902628..1903527 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| H4F96_RS09140 (1903673) | 1903673..1903723 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| H4F96_RS09145 (1904006) | 1904006..1904257 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| H4F96_RS09150 (1904254) | 1904254..1904508 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| H4F96_RS09155 (1904591) | 1904591..1905415 | + | 825 | WP_000754749.1 | SDR family oxidoreductase | - |
| H4F96_RS09160 (1905461) | 1905461..1906390 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| H4F96_RS09165 (1906605) | 1906605..1906667 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| H4F96_RS09170 (1906657) | 1906657..1908015 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| H4F96_RS09175 (1908194) | 1908194..1909252 | + | 1059 | WP_023568741.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| H4F96_RS09180 (1909266) | 1909266..1909493 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T202769 WP_000767829.1 NZ_CP075062:1904254-1904508 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T202769 NZ_CP099608:c1733120-1732545 [Pseudomonas moraviensis]
GTGAGGCATTCCTCTTTCACTGCTGTATACGATGCATGCGTCTTATATCCGGCCCCTTTGAGAGACTTCCTTATGTGGCT
CGCGTTGTCTGGGCTGTATCGAGCTCGCTGGACTCAGGAAATACACCACGAATGGAAGCGTAACTTATTGAAGAACAGGT
CCGACCTGACCCTCGAACAACTCGATCGCACATCGCAATTGATGGACCTGGCCATTCCAGATGCGTGTATCGATGGCTAT
GAAGACTTGGTGTCAGGTCTGACGCTGCCTGATGAGAACGACCGCCATGTTCTGGCGGCCGCTATCCGATGCGGTGCCGA
TGTAATAGTGACGTTCAACCTGAAAGATTTCCCCTCCTGTCATCTCGCGCCATATGGCATCGAAGCTCAGCACCCGGATG
AGTTTGTGGAAAACCTTTTTCATCTTGATTCGGCTGCCGTCGTCGCTGCGGCCCAAAGCCAGCGACGGCAATTGAAAACG
CCCACTGTGGAGGTGGACAAATATCTTGGCTTTCTCCAGCGGCAAGGCTTGGTCGAATCGGTAAAGGCGTTAGGTAACTA
TCGTGCGATTCTCTGA
GTGAGGCATTCCTCTTTCACTGCTGTATACGATGCATGCGTCTTATATCCGGCCCCTTTGAGAGACTTCCTTATGTGGCT
CGCGTTGTCTGGGCTGTATCGAGCTCGCTGGACTCAGGAAATACACCACGAATGGAAGCGTAACTTATTGAAGAACAGGT
CCGACCTGACCCTCGAACAACTCGATCGCACATCGCAATTGATGGACCTGGCCATTCCAGATGCGTGTATCGATGGCTAT
GAAGACTTGGTGTCAGGTCTGACGCTGCCTGATGAGAACGACCGCCATGTTCTGGCGGCCGCTATCCGATGCGGTGCCGA
TGTAATAGTGACGTTCAACCTGAAAGATTTCCCCTCCTGTCATCTCGCGCCATATGGCATCGAAGCTCAGCACCCGGATG
AGTTTGTGGAAAACCTTTTTCATCTTGATTCGGCTGCCGTCGTCGCTGCGGCCCAAAGCCAGCGACGGCAATTGAAAACG
CCCACTGTGGAGGTGGACAAATATCTTGGCTTTCTCCAGCGGCAAGGCTTGGTCGAATCGGTAAAGGCGTTAGGTAACTA
TCGTGCGATTCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT202769 WP_001259255.1 NZ_CP075062:1904006-1904257 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT202769 NZ_CP099608:c1733584-1733117 [Pseudomonas moraviensis]
ATGCCCACTCCAATTCCTTCCACTACAAATTTGCCAGTTGAACGCGAAGTCAAAGCCGCGATTGAAGGCCAGCGCACCCT
CACCGCTTTCCTCGCCACAGGTTTCGATACCCAGCGAATCCAGATTTTTGATGAGCAGAATGAAGCCCACAGCGTCGAGC
TGCCAACGTCGGCATTGCGCTTGCTGAGCGATATCCTCGCAGCGCTGGCGGAGGGCAACGCTGTGAAGGTCGTGCCGATC
CATGCCGAGCTGACCACTCAAGAAGCTGCCGATCTGCTCAACGTCTCACGTCCGCACATGATCAAACTGCTGGAGAGCGG
TGAGATTTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGAATATAAAACCCGGCGAGACA
CCGCCAGCGAGCAGGCAATGACGCTTCTCGCGGAGCAGGCACAGGCGCTAAGGACAGGATACGAGTGA
ATGCCCACTCCAATTCCTTCCACTACAAATTTGCCAGTTGAACGCGAAGTCAAAGCCGCGATTGAAGGCCAGCGCACCCT
CACCGCTTTCCTCGCCACAGGTTTCGATACCCAGCGAATCCAGATTTTTGATGAGCAGAATGAAGCCCACAGCGTCGAGC
TGCCAACGTCGGCATTGCGCTTGCTGAGCGATATCCTCGCAGCGCTGGCGGAGGGCAACGCTGTGAAGGTCGTGCCGATC
CATGCCGAGCTGACCACTCAAGAAGCTGCCGATCTGCTCAACGTCTCACGTCCGCACATGATCAAACTGCTGGAGAGCGG
TGAGATTTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGAATATAAAACCCGGCGAGACA
CCGCCAGCGAGCAGGCAATGACGCTTCTCGCGGAGCAGGCACAGGCGCTAAGGACAGGATACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|