Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 423..1074 Replicon plasmid unnamed5
Accession NZ_CP074711
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name higB Uniprot ID V2UF49
Locus tag KIP77_RS19885 Protein ID WP_000269909.1
Coordinates 423..779 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KIP77_RS19890 Protein ID WP_001140621.1
Coordinates 772..1074 (+) Length 101 a.a.

Genomic Context

KIP77_RS19885KIP77_RS19890KIP77_RS19895KIP77_RS19900KIP77_RS19905KIP77_RS19910KIP77_RS19915KIP77_RS19920KIP77_RS19925KIP77_RS19930
Location: 423..779 (357 bp)
Type: Toxin
Protein ID: WP_000269909.1
Location: 772..1074 (303 bp)
Type: Antitoxin
Protein ID: WP_001140621.1
Location: 1067..1276 (210 bp)
Type: Others
Protein ID: WP_000069472.1
Location: 1413..1883 (471 bp)
Type: Others
Protein ID: WP_229997907.1
Location: 1991..2542 (552 bp)
Type: Others
Protein ID: WP_229997908.1
Location: 2549..2848 (300 bp)
Type: Others
Protein ID: WP_229997909.1
Location: 2865..3263 (399 bp)
Type: Others
Protein ID: WP_229997910.1
Location: 3461..4072 (612 bp)
Type: Others
Protein ID: WP_000571899.1
Location: 4288..4806 (519 bp)
Type: Others
Protein ID: WP_000447196.1
Location: 4845..5357 (513 bp)
Type: Others
Protein ID: WP_001089572.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KIP77_RS19885 (KIP77_19755)423..779+357WP_000269909.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KIP77_RS19890 (KIP77_19760)772..1074+303WP_001140621.1XRE family transcriptional regulatorAntitoxin
KIP77_RS19895 (KIP77_19765)1067..1276+210WP_000069472.1hypothetical protein-
KIP77_RS199001413..1883+471WP_229997907.1DUF262 domain-containing protein-
KIP77_RS199051991..2542+552WP_229997908.1hypothetical protein-
KIP77_RS19910 (KIP77_19775)2549..2848+300WP_229997909.1hypothetical protein-
KIP77_RS19915 (KIP77_19780)2865..3263+399WP_229997910.1hypothetical protein-
KIP77_RS19920 (KIP77_19785)3461..4072+612WP_000571899.1recombinase family protein-
KIP77_RS19925 (KIP77_19790)4288..4806+519WP_000447196.1tetratricopeptide repeat protein-
KIP77_RS19930 (KIP77_19795)4845..5357+513WP_001089572.1SMI1/KNR4 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..3811838118


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13515.49 Da        Isoelectric Point: 6.4631

>T202700 WP_000269909.1 NZ_CP074711:423-779 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

>T202700 NZ_CP099590:648519-648833 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11179.02 Da        Isoelectric Point: 7.3198

>AT202700 WP_001140621.1 NZ_CP074711:772-1074 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT202700 NZ_CP099590:648830-649246 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBV2UF49

Antitoxin

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Source
ID
Structure
No matching records found

References