Detailed information of TA system TA202639

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4132615..4133027
• Replicon: chromosome
• Accession: NZ_CP074680
• Organism: Escherichia coli strain MEI008

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: KIM92_RS19990
• Protein ID: WP_000132601.1
• Coordinates: 4132686..4133027 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4132615..4132691 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KIM92_RS19980 (4129478)	4129478..4131067	+	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-
KIM92_RS19985 (4131064)	4131064..4132458	+	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
- (4132615)	4132615..4132691	-	77	NuclAT_10	-	Antitoxin
- (4132615)	4132615..4132691	-	77	NuclAT_10	-	Antitoxin
- (4132615)	4132615..4132691	-	77	NuclAT_10	-	Antitoxin
- (4132615)	4132615..4132691	-	77	NuclAT_10	-	Antitoxin
- (4132615)	4132615..4132691	-	77	NuclAT_11	-	Antitoxin
- (4132615)	4132615..4132691	-	77	NuclAT_11	-	Antitoxin
- (4132615)	4132615..4132691	-	77	NuclAT_11	-	Antitoxin
- (4132615)	4132615..4132691	-	77	NuclAT_11	-	Antitoxin
KIM92_RS19990 (4132686)	4132686..4133027	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
KIM92_RS19995 (4133189)	4133189..4134568	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
KIM92_RS20000 (4134568)	4134568..4135614	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T202639 WP_000132601.1 NZ_CP074680:4132686-4133027 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T202639 NZ_CP099542:1569879-1570199 [Pantoea ananatis]
ATGCACATTTCAACTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTACAGGTGTGGAAGCAACTGTTAAC
GTATCTGCTGGATCACCATTACGGCCTGACACTTAACGACACGCCATTCCATGACGACGCGGCCATTGAGGAGCATATCG
ACGCGGGAATAACGCTTGCGGATGCGGTTAATTTCCTCGTGGAACGTCATGAACTGGTACGTATCGACCATAAAGGATTT
ACATGGTATGAGCAGACATCATTCTTGACCGCTACCGATATTCTCAGAGCCAGGCGAGCTACCGGATTAATAAATACCTG
A

Antitoxin

Nucleotide

• Length: 77 bp

>AT202639 NZ_CP074680:c4132691-4132615 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin