Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4673045..4673799 | Replicon | chromosome |
| Accession | NZ_CP074663 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | BG493_RS22595 | Protein ID | WP_000558166.1 |
| Coordinates | 4673045..4673356 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | BG493_RS22600 | Protein ID | WP_001259011.1 |
| Coordinates | 4673353..4673799 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BG493_RS22565 (4668703) | 4668703..4669605 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| BG493_RS22570 (4669602) | 4669602..4670237 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| BG493_RS22575 (4670234) | 4670234..4671163 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| BG493_RS22580 (4671210) | 4671210..4671500 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| BG493_RS22585 (4671501) | 4671501..4671812 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| BG493_RS22590 (4672030) | 4672030..4672959 | + | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
| BG493_RS22595 (4673045) | 4673045..4673356 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| BG493_RS22600 (4673353) | 4673353..4673799 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| BG493_RS22605 (4673814) | 4673814..4674755 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| BG493_RS22610 (4674800) | 4674800..4675237 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| BG493_RS22615 (4675234) | 4675234..4676106 | - | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
| BG493_RS22620 (4676100) | 4676100..4676699 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| BG493_RS22625 (4676890) | 4676890..4677693 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| BG493_RS22630 (4677727) | 4677727..4678623 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T202587 WP_000558166.1 NZ_CP074663:4673045-4673356 [Salmonella enterica subsp. enterica serovar Typhimurium]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T202587 NZ_CP099511:3718062-3718436 [Lelliottia amnigena]
ATGGCGAAAGGGTCTGCTCTTTTTGACACCAATATTCTCATCGACTTGTTCAGTGGAAGGGCAGAGGCAAAGCACGCATT
AGAGAGTTGGCCGCCGCAAAATGCGATTAGCATCATCACCTGGATGGAAGTCATGGTGGGAGCAAAAAAATACCATCAGG
AGCATCGTACCCGGATTGCCTTAAGTGCGTTTAACGTCCTTGGTGTTTCACAAGAGGTTGCTGAGCGGAGTGTTGATCTC
CGGCAGGAGTATCGAATGAAGCTCCCGGATGCCATTATTCTGGCTACTGCACAAATTCATCGTCTTGAACTGGTTACGCG
TAATACCAAGGATTTCGGTAACATCCCTGATGTGGTCACGCCCTACAATTTGTAG
ATGGCGAAAGGGTCTGCTCTTTTTGACACCAATATTCTCATCGACTTGTTCAGTGGAAGGGCAGAGGCAAAGCACGCATT
AGAGAGTTGGCCGCCGCAAAATGCGATTAGCATCATCACCTGGATGGAAGTCATGGTGGGAGCAAAAAAATACCATCAGG
AGCATCGTACCCGGATTGCCTTAAGTGCGTTTAACGTCCTTGGTGTTTCACAAGAGGTTGCTGAGCGGAGTGTTGATCTC
CGGCAGGAGTATCGAATGAAGCTCCCGGATGCCATTATTCTGGCTACTGCACAAATTCATCGTCTTGAACTGGTTACGCG
TAATACCAAGGATTTCGGTAACATCCCTGATGTGGTCACGCCCTACAATTTGTAG
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT202587 WP_001259011.1 NZ_CP074663:4673353-4673799 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT202587 NZ_CP099511:3717820-3718062 [Lelliottia amnigena]
ATGATGGCGGGAAGATACATGGGCAGAATTCTACTCGATCTATCAGACGAGGTGATAAAACGGCTGGACGACCTCAAGGT
GCACCGGAACGTCCCTCGCGCTGAATTGTTACGGGAAGCCGTTGAGCAATATCTTGAAAGACACGATCAGGCTGAAAGCA
CGATCTCAGATGCCCTTGGCCTGTGGCATGGCTGTGAGGAAGAGGGTGTTGATTATCAGCGCAAGCTTCGTGAGGAGTGG
TAA
ATGATGGCGGGAAGATACATGGGCAGAATTCTACTCGATCTATCAGACGAGGTGATAAAACGGCTGGACGACCTCAAGGT
GCACCGGAACGTCCCTCGCGCTGAATTGTTACGGGAAGCCGTTGAGCAATATCTTGAAAGACACGATCAGGCTGAAAGCA
CGATCTCAGATGCCCTTGGCCTGTGGCATGGCTGTGAGGAAGAGGGTGTTGATTATCAGCGCAAGCTTCGTGAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|