Detailed information of TA system TA202586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4671210..4671812
• Replicon: chromosome
• Accession: NZ_CP074663
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: BG493_RS22585
• Protein ID: WP_001159630.1
• Coordinates: 4671501..4671812 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BG493_RS22580
• Protein ID: WP_000362050.1
• Coordinates: 4671210..4671500 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG493_RS22565 (4668703)	4668703..4669605	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
BG493_RS22570 (4669602)	4669602..4670237	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
BG493_RS22575 (4670234)	4670234..4671163	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
BG493_RS22580 (4671210)	4671210..4671500	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
BG493_RS22585 (4671501)	4671501..4671812	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
BG493_RS22590 (4672030)	4672030..4672959	+	930	WP_001127703.1	alpha/beta hydrolase	-
BG493_RS22595 (4673045)	4673045..4673356	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
BG493_RS22600 (4673353)	4673353..4673799	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
BG493_RS22605 (4673814)	4673814..4674755	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
BG493_RS22610 (4674800)	4674800..4675237	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
BG493_RS22615 (4675234)	4675234..4676106	-	873	WP_000921427.1	virulence factor BrkB family protein	-
BG493_RS22620 (4676100)	4676100..4676699	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T202586 WP_001159630.1 NZ_CP074663:c4671812-4671501 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T202586 NZ_CP099511:3357393-3357680 [Lelliottia amnigena]
ATGACTGAACTCACTCATTACGATCCTGCCAGGGCGCTTATCAATGATGATGAAATTAGCGTATTCATGGCTGATGCGCT
AGAAACTGGCGATTCTGCCTACATTGCTAAAGCATTAGGGATCGTTGCCCGCACAAAAGGAATGTCTACCATTGCGACAC
AAACGGGTTTGTCTCGCGAACAGCTGTATCGCTCTTTTAGTGAAAAAGGTAACCCAACGCTTAAAACCACGCTTGCCGTT
ATGAAAGCGCTGGGTCTTGGATTGACGATTAAAAGTGCTGAAGATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT202586 WP_000362050.1 NZ_CP074663:c4671500-4671210 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT202586 NZ_CP099511:3357083-3357400 [Lelliottia amnigena]
ATGAAGGAGATTGTTCAAACAGAATCCTTCCGTTGCTGGGAGCAAAACGTAAACGATCCACGTGCAAAAACGCTTATTGC
AGCGCGTTTATTCCGCCTGGCTAATGGTCTGCCGGGGGATGTAAAACCTGTTGGAGAAGGTATCAGCGAGCTACGCATTC
ATTACGGCCCGGGTTACAGGATCTATTTTAAATCGCAGGGAAACGTACTGATCATTTTGCTCAGTGGCGGCAATAAAAAC
AGTCAGGATAAAGACATCATTCTGGCAAAGACACTCGCAAGGTCACTCGAAAATCGGGAGTTTATACACCATGACTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64