Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2458815..2459337 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag BG493_RS11990 Protein ID WP_000221343.1
Coordinates 2459053..2459337 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag BG493_RS11985 Protein ID WP_000885424.1
Coordinates 2458815..2459063 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS11960 (2454031) 2454031..2455497 + 1467 WP_000987828.1 hypothetical protein -
BG493_RS11965 (2456305) 2456305..2457019 + 715 Protein_2351 helix-turn-helix domain-containing protein -
BG493_RS11970 (2457075) 2457075..2457983 - 909 WP_077918335.1 hypothetical protein -
BG493_RS11975 (2458126) 2458126..2458458 - 333 WP_000253154.1 DUF1493 family protein -
BG493_RS11980 (2458448) 2458448..2458663 - 216 WP_000206207.1 hypothetical protein -
BG493_RS11985 (2458815) 2458815..2459063 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BG493_RS11990 (2459053) 2459053..2459337 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BG493_RS11995 (2459508) 2459508..2459897 + 390 WP_000194089.1 RidA family protein -
BG493_RS12000 (2459949) 2459949..2461028 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
BG493_RS12005 (2461221) 2461221..2461709 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
BG493_RS12010 (2461754) 2461754..2463262 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2454034..2466119 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T202578 WP_000221343.1 NZ_CP074663:2459053-2459337 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T202578 NZ_CP099508:2640169-2640531 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT202578 WP_000885424.1 NZ_CP074663:2458815-2459063 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT202578 NZ_CP099508:2640002-2640172 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References