Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4697085..4697839 | Replicon | chromosome |
| Accession | NZ_CP074606 | ||
| Organism | Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A3V9WW11 |
| Locus tag | DLM99_RS22885 | Protein ID | WP_000558159.1 |
| Coordinates | 4697085..4697396 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | DLM99_RS22890 | Protein ID | WP_001259012.1 |
| Coordinates | 4697393..4697839 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DLM99_RS22855 (4692743) | 4692743..4693645 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| DLM99_RS22860 (4693642) | 4693642..4694277 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| DLM99_RS22865 (4694274) | 4694274..4695203 | + | 930 | WP_000027735.1 | formate dehydrogenase accessory protein FdhE | - |
| DLM99_RS22870 (4695250) | 4695250..4695540 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| DLM99_RS22875 (4695541) | 4695541..4695852 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| DLM99_RS22880 (4696070) | 4696070..4696999 | + | 930 | WP_001127707.1 | alpha/beta hydrolase | - |
| DLM99_RS22885 (4697085) | 4697085..4697396 | + | 312 | WP_000558159.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| DLM99_RS22890 (4697393) | 4697393..4697839 | + | 447 | WP_001259012.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| DLM99_RS22895 (4697854) | 4697854..4698795 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| DLM99_RS22900 (4698840) | 4698840..4699277 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| DLM99_RS22905 (4699274) | 4699274..4700146 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| DLM99_RS22910 (4700140) | 4700140..4700739 | - | 600 | WP_000965698.1 | glucose-1-phosphatase | - |
| DLM99_RS22915 (4700930) | 4700930..4701733 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| DLM99_RS22920 (4701767) | 4701767..4702663 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12422.41 Da Isoelectric Point: 9.5921
>T202536 WP_000558159.1 NZ_CP074606:4697085-4697396 [Salmonella enterica subsp. enterica serovar Newport str.]
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T202536 NZ_CP099495:2618780-2618989 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG
Antitoxin
Download Length: 149 a.a. Molecular weight: 16750.08 Da Isoelectric Point: 6.6451
>AT202536 WP_001259012.1 NZ_CP074606:4697393-4697839 [Salmonella enterica subsp. enterica serovar Newport str.]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT202536 NZ_CP099495:2618475-2618768 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|