Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4695250..4695852 Replicon chromosome
Accession NZ_CP074606
Organism Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag DLM99_RS22875 Protein ID WP_001159635.1
Coordinates 4695541..4695852 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DLM99_RS22870 Protein ID WP_000362050.1
Coordinates 4695250..4695540 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLM99_RS22855 (4692743) 4692743..4693645 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
DLM99_RS22860 (4693642) 4693642..4694277 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
DLM99_RS22865 (4694274) 4694274..4695203 + 930 WP_000027735.1 formate dehydrogenase accessory protein FdhE -
DLM99_RS22870 (4695250) 4695250..4695540 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
DLM99_RS22875 (4695541) 4695541..4695852 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
DLM99_RS22880 (4696070) 4696070..4696999 + 930 WP_001127707.1 alpha/beta hydrolase -
DLM99_RS22885 (4697085) 4697085..4697396 + 312 WP_000558159.1 type II toxin-antitoxin system HigB family toxin -
DLM99_RS22890 (4697393) 4697393..4697839 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
DLM99_RS22895 (4697854) 4697854..4698795 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
DLM99_RS22900 (4698840) 4698840..4699277 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
DLM99_RS22905 (4699274) 4699274..4700146 - 873 WP_000921423.1 virulence factor BrkB family protein -
DLM99_RS22910 (4700140) 4700140..4700739 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T202535 WP_001159635.1 NZ_CP074606:c4695852-4695541 [Salmonella enterica subsp. enterica serovar Newport str.]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T202535 NZ_CP099495:2559901-2560005 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT202535 WP_000362050.1 NZ_CP074606:c4695540-4695250 [Salmonella enterica subsp. enterica serovar Newport str.]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT202535 NZ_CP099495:c2560164-2560000 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References