Detailed information of TA system TA202514

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4318361..4318963
• Replicon: chromosome
• Accession: NZ_CP074592
• Organism: Salmonella bongori serovar 40:z35:- strain CFSAN001045

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V8XMR3
• Locus tag: AIT23_RS20165
• Protein ID: WP_001159631.1
• Coordinates: 4318652..4318963 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AIT23_RS20160
• Protein ID: WP_038393391.1
• Coordinates: 4318361..4318651 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AIT23_RS20145 (4315854)	4315854..4316756	+	903	WP_000331357.1	formate dehydrogenase subunit beta	-
AIT23_RS20150 (4316753)	4316753..4317388	+	636	WP_000829030.1	formate dehydrogenase cytochrome b556 subunit	-
AIT23_RS20155 (4317385)	4317385..4318314	+	930	WP_020845723.1	formate dehydrogenase accessory protein FdhE	-
AIT23_RS20160 (4318361)	4318361..4318651	-	291	WP_038393391.1	DNA-binding transcriptional regulator	Antitoxin
AIT23_RS20165 (4318652)	4318652..4318963	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
AIT23_RS20170 (4319181)	4319181..4320095	+	915	WP_079773454.1	alpha/beta hydrolase	-
AIT23_RS20175 (4320121)	4320121..4321062	-	942	WP_179124420.1	fatty acid biosynthesis protein FabY	-
AIT23_RS20180 (4321107)	4321107..4321544	-	438	WP_038393387.1	D-aminoacyl-tRNA deacylase	-
AIT23_RS20185 (4321541)	4321541..4322413	-	873	WP_038393385.1	virulence factor BrkB family protein	-
AIT23_RS20190 (4322407)	4322407..4323006	-	600	WP_000965694.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-74)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12312.25 Da
• Isoelectric Point: 9.4460

>T202514 WP_001159631.1 NZ_CP074592:c4318963-4318652 [Salmonella bongori serovar 40:z35:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T202514 NZ_CP099489:c3587585-3587181 [Ornithinimicrobium sp. HY1793]
GTGATCGTCGATACCTCAGCGTGGATCGAGTTCTTGCGACCGGGCCCGTCGGGCGCTGGTGATCAACTCGAGTCGCTCAT
CCGGAAGCAAGAGCGCCTGGTGATCCCGGAGGTGGTGCTGATGGAACTGCTCAGCGGCACGACCGACGAGGCGCTCGCCG
CACGACGGCGCCGGTTGATTGAGTCCTTCGAGTTGACACCCACGGAGCCGATCGTGGACTCACTTGCGGCCGCATCACTG
CAGCGGATGTGCCGCCGCGGGGGTGAGTCCGTGCGGAACCTCGGTGACTGCCTGATTGCCAGCGTCGCGCTGCGCCTCGA
CCTCCCGGTGATGCACCGTGATCGCGACTTTGAGGTGCTCAGGCGACATTGCGGCATACGGACTGTTTCGTTGATCGGCG
CCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10945.56 Da
• Isoelectric Point: 10.8907

>AT202514 WP_038393391.1 NZ_CP074592:c4318651-4318361 [Salmonella bongori serovar 40:z35:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRH

Nucleotide

• Length: 291 bp

>AT202514 NZ_CP099489:c3587791-3587582 [Ornithinimicrobium sp. HY1793]
ATGGCGCGCACGAACATCGATATCGATGAGGACCTGGTGGCCGCGGTGATGGCACGCTTCCGGCTCGGGTCCAAGCGAGC
TGCCGTCGACTTCGCGTTGCAGCAGCTCATCCGCGAGCCGATGACGACCGAAGAGGTCCTGGCGATGAGGGGCAGCGGCT
TTGAGGTCGACAATGATGAGATCGAGGGAGACTGGGCGGCGAGCAGGTGA

Structures

Toxin

• AlphaFold DB: A0A3V8XMR3