Detailed information of TA system TA202441

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4629915..4630137
• Replicon: chromosome
• Accession: NZ_CP074576
• Organism: Escherichia coli strain CS18F

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: KHZ70_RS22345
• Protein ID: WP_001295224.1
• Coordinates: 4630030..4630137 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4629915..4629973 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KHZ70_RS22320	4625800..4626804	+	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
KHZ70_RS22325	4626834..4628105	-	1272	WP_001318103.1	aromatic amino acid transport family protein	-
KHZ70_RS22330	4628581..4628688	+	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
KHZ70_RS22335	4629064..4629171	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
KHZ70_RS22340	4629547..4629654	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	4629915..4629973	-	59	-	-	Antitoxin
KHZ70_RS22345	4630030..4630137	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
KHZ70_RS22350	4630224..4631903	-	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
KHZ70_RS22355	4631900..4632091	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
KHZ70_RS22360	4632088..4633659	-	1572	WP_001204944.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
KHZ70_RS22365	4633932..4634120	+	189	WP_001063315.1	cellulose biosynthesis protein BcsR	-
KHZ70_RS22370	4634132..4634884	+	753	WP_000279544.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T202441 WP_001295224.1 NZ_CP074576:4630030-4630137 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T202441 NZ_CP099390:4654224-4654601 [Citrobacter braakii]
ATGCAAACCCAACCACTATCCTCAACGCGGGAGGCCTCACCACGCCCGTCTCCCGTTGAAATCTGGCAGCAGGTCCTGAG
CCACCTGCTGGACCAGCACTACGGTCTGACGCTGAACGATACGCCGTTTAGCAACGATGGCGCGATTCAGGAGCACATTG
ACGCGGGGATTTCACTCTGTGACGCCGTCAATTTTATCGTCGAAAAGTATGAACTGGTCCGTATCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCTCCACTTATCGGTTGTATTGACATTCTCCGCGCCCGTAAAGCCTGTGGACTCATAACCCGCAA
CAGATACAAAGCGGTTACCAATATCACCCGCGGCAAATACAGCAAGGTGCAACAATGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT202441 NZ_CP074576:c4629973-4629915 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin