Detailed information of TA system TA202413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 2629025..2630372
• Replicon: chromosome
• Accession: NZ_CP074572
• Organism: Shewanella dokdonensis strain DSM 23626

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: KHX94_RS12680
• Protein ID: WP_213680924.1
• Coordinates: 2629335..2630372 (+)
• Length: 346 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: KHX94_RS12675
• Protein ID: WP_213680923.1
• Coordinates: 2629025..2629333 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KHX94_RS12660 (KHX94_12655)	2624983..2626827	-	1845	WP_213680920.1	di-heme oxidoredictase family protein	-
KHX94_RS12665 (KHX94_12660)	2626794..2628041	-	1248	WP_213680921.1	discoidin domain-containing protein	-
KHX94_RS12670 (KHX94_12665)	2628708..2629040	+	333	WP_213680922.1	hypothetical protein	-
KHX94_RS12675 (KHX94_12670)	2629025..2629333	+	309	WP_213680923.1	HipA N-terminal domain-containing protein	Antitoxin
KHX94_RS12680 (KHX94_12675)	2629335..2630372	+	1038	WP_213680924.1	HipA domain-containing protein	Toxin
KHX94_RS12685 (KHX94_12680)	2630917..2631120	-	204	WP_213680925.1	hypothetical protein	-
KHX94_RS12690 (KHX94_12685)	2631292..2631472	-	181	Protein_2528	IS256 family transposase	-
KHX94_RS12695 (KHX94_12690)	2631798..2632103	-	306	WP_213680926.1	hypothetical protein	-
KHX94_RS12700 (KHX94_12695)	2632223..2633089	+	867	WP_213680927.1	nitrogenase iron protein	-
KHX94_RS12705 (KHX94_12700)	2633138..2634604	+	1467	WP_213680928.1	nitrogenase molybdenum-iron protein alpha chain	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (57-297)

Antitoxin

• HipA, N-terminal subdomain 1 (5-99)

Sequences

Toxin

Protein

• Length: 346 a.a.
• Molecular weight: 38597.56 Da
• Isoelectric Point: 7.3963

>T202413 WP_213680924.1 NZ_CP074572:2629335-2630372 [Shewanella dokdonensis]
MSNCRITLQTLLTPAEQKTGFSKAGMKALAGASRISFELPFTAAEFVQQKPAKQKGMSISGAQPKLQLTLDVAKRHFDII
DSQGDFILKPSPPEFPYLAENEHCIMSVMKQLKFVVPPFGMLQFAPEAGKAVEYAFVIKRFDRAADGSKIHQEQLDGAMN
IAEKYGRIDAGKQMVSYETIGRFLKDHNVIKTLVDVRDFFRRVAYAYLLGNNDLHLRNFGIVALNRLAPVYDFVSVAPYP
TYFASGYLALPLLTIEEGEQQLAPGFETAYGEYLGIDFLQFAKGIGLSEKFALAIIQRDFPKEADKVLSVINDSHMPEEM
KAVVSNCFRQRSNRMQIVSTEQIDV

Nucleotide

• Length: 1038 bp

>T202413 NZ_CP099386:4697845-4698156 [Citrobacter braakii]
ATGCATGTTATCAGCCGAAAACCTTTCAACGAGGCAATACTCCGTTTTCCAAACCACATGGCAGCACTCGTTGATTTGCT
GAATATTTTAGAGAAAAAAATGTTCCACACTCCTGAAGAGATGAAGCAGTACATACCTTCACTGGATAATTTTAAATACA
GAAATAAATGGTGGGTGATTAATGTTTCAGGTAACTGCTTGAGACTTATTGCCTATATTGATTTCAAACTGCAAAAGGTA
TTTGTGAAGCATATCGTTCACCATGCCGAGTATGACAGACTAACCACATACTATCGGGGTCACAAAGAATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11560.10 Da
• Isoelectric Point: 5.5405

>AT202413 WP_213680923.1 NZ_CP074572:2629025-2629333 [Shewanella dokdonensis]
MYRKVMVLLHGVHAGDLTQQDDQYSFQYLADYAGPRISLSLPVRTEPYVSQGALHPYFSSLAPEGWLRRVYSNQQKIDEN
DLLGILMENGDNLLGAIQIKGY

Nucleotide

• Length: 309 bp

>AT202413 NZ_CP099386:4698153-4698605 [Citrobacter braakii]
ATGAGAACGCATGAAAGCCATCAGATAGAAACAGCCAGTGTAAAATTGATGATCGATACCTTTACCGATGCAGTGAAAAA
AATCCCCCTGTTAGGCAAAGAACAAAATGAGACAGAGTACCGAAAAGCACTCGCTTTGGTGGAGTTTCTGGTTGATCGTG
ACGACCTGGAAAACCCGTTGTTTGAGCTGCTTTCAGCTCGGATCCGCGACTACGAAAAACATGCGCCTGAGTTCAGTGCC
CTCAACCAACAACTGGAACATACTCCTCATGGCGTTACGTTACTGCGTACGCTCATGGATCAATATGGTCTCAAAGCAGC
AGATCTTGCCAACGAACTTGGTTCAAAATCCAATGTCAGCAACATCTTGAATGGTCGCAGAGCACTGACTGTAAGTCATA
TTAAAATGCTCGCAGAACGCTTTAACCTTCCGGCAGACGCATTCATCGAGTAA