Detailed information of TA system TA202411

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 16462..17062
• Replicon: chromosome
• Accession: NZ_CP074572
• Organism: Shewanella dokdonensis strain DSM 23626

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KHX94_RS00140
• Protein ID: WP_244859259.1
• Coordinates: 16751..17062 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KHX94_RS00135
• Protein ID: WP_213681924.1
• Coordinates: 16462..16749 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KHX94_RS00090 (KHX94_00090)	11550..11981	+	432	WP_213681915.1	hypothetical protein	-
KHX94_RS00095 (KHX94_00095)	11975..12253	+	279	WP_213681916.1	hypothetical protein	-
KHX94_RS00100 (KHX94_00100)	12467..12793	+	327	WP_213681917.1	hypothetical protein	-
KHX94_RS00105 (KHX94_00105)	12855..13457	+	603	WP_213681918.1	hypothetical protein	-
KHX94_RS00110 (KHX94_00110)	13573..13971	-	399	WP_213681919.1	hypothetical protein	-
KHX94_RS00115 (KHX94_00115)	14506..14814	-	309	WP_213681920.1	hypothetical protein	-
KHX94_RS00120 (KHX94_00120)	15330..15755	-	426	WP_213681921.1	hypothetical protein	-
KHX94_RS00125 (KHX94_00125)	15966..16163	+	198	WP_213681922.1	hypothetical protein	-
KHX94_RS00130 (KHX94_00130)	16160..16450	+	291	WP_213681923.1	ogr/Delta-like zinc finger family protein	-
KHX94_RS00135 (KHX94_00135)	16462..16749	-	288	WP_213681924.1	NadS family protein	Antitoxin
KHX94_RS00140 (KHX94_00140)	16751..17062	-	312	WP_244859259.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KHX94_RS00145 (KHX94_00145)	17506..17670	+	165	WP_213681925.1	host cell division inhibitor Icd-like protein	-
KHX94_RS00150 (KHX94_00150)	17667..18518	+	852	WP_213681926.1	3'-5' exonuclease	-
KHX94_RS00155 (KHX94_00155)	18515..18775	+	261	WP_213681927.1	hypothetical protein	-
KHX94_RS00160 (KHX94_00160)	18772..19329	+	558	WP_213681928.1	hypothetical protein	-
KHX94_RS00165 (KHX94_00165)	19313..19516	+	204	WP_213681929.1	hypothetical protein	-
KHX94_RS00170 (KHX94_00170)	19513..21057	+	1545	WP_213681930.1	toprim domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	50..23874	23824

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12238.30 Da
• Isoelectric Point: 9.3575

>T202411 WP_244859259.1 NZ_CP074572:c17062-16751 [Shewanella dokdonensis]
MLFIETEFFTRQVKELMPDDMYRELQQYLADNPEAGPVIQGTGGLRKLRWQMPGRGKRGGVRVIYYHVELLSHIRLLMMY
PKNEQEDLTAEQKKLLKAIVERW

Nucleotide

• Length: 312 bp

>T202411 NZ_CP099386:c4259068-4258787 [Citrobacter braakii]
ATGACCTATAACCTGGAGTTTTTAGATATTGCGCTCAAGGAGTGGCGCAAGCTTTCCCCTGCATTACGCGAGCAGTTCAA
AAAGAAACTGGCGGAGCGGCTGGAAAATCCCCATGTCCCTGCCGCCCGCCTTTCCGGCAAATTACACCGTTACAAAATCA
AGCTTCGCAGTGCCGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCAGTGGGCAGA
CGTGATGGTGATGAGGTTTATCATCAGGCTAACCGGCGCTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10867.55 Da
• Isoelectric Point: 8.7343

>AT202411 WP_213681924.1 NZ_CP074572:c16749-16462 [Shewanella dokdonensis]
MNDALFEELLASVQQMDEIVKGEREPSREAVVMAVKVKSIREKTNLTQSKFAKLIDVNIGTLRNWEQGRREPTGPAKTLL
RLIERDPEHVLRALN

Nucleotide

• Length: 288 bp

>AT202411 NZ_CP099386:c4259306-4259058 [Citrobacter braakii]
ATGCCATTTCATATCCTGACCAAAACCGCTGCCAGTATCACCGACCTGAAACGTAACCCAATGGGGACAGTCAACGCCGG
GGAGGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCAGCGTTTTACTGCGTGCCGCCTGCGGTTTATGCGTATCTGC
TGGAGCTGGCAGAAGACGCCGAGCTGAACCGTATCGCCGACGAACGTGAAGATGGAAAGCGAATAAAGGTGTCTTTAAAT
GACCTATAA