Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 666081..666714 Replicon chromosome
Accession NZ_CP074570
Organism Paraneptunicella aestuarii strain NBU2194

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KIH87_RS02805 Protein ID WP_232360025.1
Coordinates 666382..666714 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KIH87_RS02800 Protein ID WP_232360024.1
Coordinates 666081..666395 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIH87_RS02780 (KIH87_02795) 661609..661845 + 237 WP_232360020.1 hypothetical protein -
KIH87_RS02785 (KIH87_02800) 662060..662350 + 291 WP_232360021.1 hypothetical protein -
KIH87_RS02790 (KIH87_02805) 662411..663214 + 804 WP_232360022.1 hypothetical protein -
KIH87_RS02795 (KIH87_02810) 663215..665968 - 2754 WP_232360023.1 P-loop NTPase fold protein -
KIH87_RS02800 (KIH87_02815) 666081..666395 - 315 WP_232360024.1 DNA-binding transcriptional regulator Antitoxin
KIH87_RS02805 (KIH87_02820) 666382..666714 - 333 WP_232360025.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KIH87_RS02810 (KIH87_02825) 666805..667161 - 357 WP_232360026.1 type II toxin-antitoxin system RelE/ParE family toxin -
KIH87_RS02815 (KIH87_02830) 667119..667355 - 237 WP_232360027.1 addiction module protein -
KIH87_RS02820 (KIH87_02835) 667455..669284 - 1830 WP_232360028.1 ABC transporter ATP-binding protein -
KIH87_RS02825 (KIH87_02840) 669358..670860 - 1503 WP_232360029.1 amidase -
KIH87_RS02830 (KIH87_02845) 671026..671415 - 390 WP_232360030.1 GFA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(8-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13238.21 Da        Isoelectric Point: 9.4330

>T202400 WP_232360025.1 NZ_CP074570:c666714-666382 [Paraneptunicella aestuarii]
MESIFIESTLFEKHRKDYLSDEDFRLLQAQLMYYPEQGDVIQGTGGLRKVRFAGKDKGKRGGFRIIYYYLSHYRRFYLLT
IYAKNEMTDLTAAQKKLLREFMEKWIDEQS

Download         Length: 333 bp

>T202400 NZ_CP099385:c4308715-4308428 [Citrobacter braakii]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCACAAAGTAACCACCGTAAACATGGTGTTCGCTTTGAGGACGCAAT
ATTGGTTTTCGACGATCCCCAACATCTGTCGCGGCAGGATCGGTATGAGAACAGTGAGTATCGCTGGCAGACCATCGGTC
TTGTTCATGGCATTGTGGTTATTCTGGTTGCCCATAGCGTTAGGTTTGAAAGTGGCTTTGAAGTCATTCGTATCATCAGT
GCCAGAAAGGCAGATCGTAAAGAGAGGAATCGTTATGAGCATAGTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11835.46 Da        Isoelectric Point: 8.6430

>AT202400 WP_232360024.1 NZ_CP074570:c666395-666081 [Paraneptunicella aestuarii]
MNNRNLFAELSSSLVEAKAHSEGKLTLKNHKVNHVNELDISPEEIVSIREKYNMSRGVFARLMHTSARTLENWEQGRSVP
NGQAITLLRLVQRHPETLGYIAEL

Download         Length: 315 bp

>AT202400 NZ_CP099385:c4308441-4308139 [Citrobacter braakii]
ATGAGCATAGTTAAACATAAACGCGGCAGCGTATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
TAAACCGGACGATGATATTGATTACAGCGACATTCCCGTGACCGAGGATAAGCAGTGGTCAGAGGCCATTCGCGGTAAGT
TTTTTCGTCCGTTGAAAACGCAGGCGTCGGTGCGCATTGATGCCGATGTGATGGAGTGGCTGAAACGCCCAGGAAAAGGA
TATCAGACGCGCCTTAATGCCATTTTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References