202382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 737580..738355 Replicon chromosome
Accession NZ_CP074558
Organism Klebsiella pneumoniae strain S39_CRE40

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag KHW03_RS03685 Protein ID WP_004150910.1
Coordinates 737870..738355 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag KHW03_RS03680 Protein ID WP_004150912.1
Coordinates 737580..737873 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW03_RS03660 (KHW03_03655) 732788..733390 - 603 WP_002916735.1 short chain dehydrogenase -
KHW03_RS03665 (KHW03_03660) 733488..734399 + 912 WP_004188550.1 LysR family transcriptional regulator -
KHW03_RS03670 (KHW03_03665) 734400..735548 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
KHW03_RS03675 (KHW03_03670) 735559..736935 - 1377 WP_004217775.1 cystathionine beta-synthase -
KHW03_RS03680 (KHW03_03675) 737580..737873 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
KHW03_RS03685 (KHW03_03680) 737870..738355 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
KHW03_RS03690 (KHW03_03685) 739059..739652 + 594 WP_004188553.1 hypothetical protein -
KHW03_RS03695 (KHW03_03690) 739749..739965 + 217 Protein_726 transposase -
KHW03_RS03700 (KHW03_03695) 740571..741443 + 873 WP_004188557.1 ParA family protein -
KHW03_RS03705 (KHW03_03700) 741443..741826 + 384 WP_004150906.1 hypothetical protein -
KHW03_RS03710 (KHW03_03705) 741819..743186 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 739749..739901 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T202382 WP_004150910.1 NZ_CP074558:737870-738355 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T202382 NZ_CP099382:c4383776-4383489 [Citrobacter braakii]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCACAAAGTAACCACCGTAAACATGGTGTTCGCTTTGAGGACGCAAT
ATTGGTTTTCGACGATCCCCAACATCTGTCGCGGCAGGAGCGGTATGAGAACGGTGAGTATCGCTGGCAGACCATTGGTC
TCGTTCATGGCATTGTGGTTATTCTGGTTGCCCATAGCGTTAGGTTTGAAAGTCGCTTTGAAGTCATTCGTATCATCAGC
GCCAGAAAGGCAGATCGTAAAGAGAGGAATCGTTATGAGCATAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT202382 WP_004150912.1 NZ_CP074558:737580-737873 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT202382 NZ_CP099382:c4383502-4383200 [Citrobacter braakii]
ATGAGCATAGTTAAACATAAACGCGGCAGCGTATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
TAAACCGGACGATGATATCGATTACAGCGACATTCCCGTGACCGAAGATAAGCAGTGGTCAGAGGCCATTCGCGGTAAGT
TTTTTCGTCCGTTAAAAACGCAGGCGTCGGTGCGCATTGATGCCGATGTGATGGAATGGCTGAAGCGCCCCGGGAAGGGT
TACCAGACGCGTCTCAATGCCATTTTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References