Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 357338..357984 Replicon chromosome
Accession NZ_CP074519
Organism Klebsiella pneumoniae strain S10_CRE10

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag KHV94_RS01650 Protein ID WP_016529833.1
Coordinates 357338..357685 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag KHV94_RS01655 Protein ID WP_002920557.1
Coordinates 357685..357984 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV94_RS01640 (353264) 353264..354697 + 1434 WP_002920564.1 glycogen synthase GlgA -
KHV94_RS01645 (354715) 354715..357162 + 2448 WP_002920561.1 glycogen phosphorylase -
KHV94_RS01650 (357338) 357338..357685 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHV94_RS01655 (357685) 357685..357984 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
KHV94_RS01660 (358047) 358047..359555 - 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
KHV94_RS01665 (359760) 359760..360089 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
KHV94_RS01670 (360140) 360140..360970 + 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
KHV94_RS01675 (361020) 361020..361778 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T202218 WP_016529833.1 NZ_CP074519:357338-357685 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T202218 NZ_CP099349:c481921-481643 [Escherichia fergusonii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGTGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATCTCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT202218 WP_002920557.1 NZ_CP074519:357685-357984 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT202218 NZ_CP099349:c481643-481359 [Escherichia fergusonii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAGCTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTTACCGGAAAAGCGGCATTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTAGATGTGTCGCGACTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References