Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 331150..331736 Replicon chromosome
Accession NZ_CP074519
Organism Klebsiella pneumoniae strain S10_CRE10

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag KHV94_RS01540 Protein ID WP_023285605.1
Coordinates 331368..331736 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag KHV94_RS01535 Protein ID WP_004174006.1
Coordinates 331150..331371 (+) Length 74 a.a.

Genomic Context

KHV94_RS01515KHV94_RS01520KHV94_RS01525KHV94_RS01530KHV94_RS01535KHV94_RS01540KHV94_RS01545KHV94_RS01550KHV94_RS01555KHV94_RS01560
Location: 327307..328233 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Location: 328230..329507 (1278 bp)
Type: Others
Protein ID: WP_004174005.1
Location: 329504..330271 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Location: 330273..330986 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Location: 331150..331371 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 331368..331736 (369 bp)
Type: Toxin
Protein ID: WP_023285605.1
Location: 332009..333325 (1317 bp)
Type: Others
Protein ID: WP_002920796.1
Location: 333432..334319 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Location: 334316..335161 (846 bp)
Type: Others
Protein ID: WP_004145129.1
Location: 335163..336233 (1071 bp)
Type: Others
Protein ID: WP_004150074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KHV94_RS01515 (327307)327307..328233+927WP_002920807.1high-affinity branched-chain amino acid ABC transporter permease LivH-
KHV94_RS01520 (328230)328230..329507+1278WP_004174005.1branched chain amino acid ABC transporter permease LivM-
KHV94_RS01525 (329504)329504..330271+768WP_002920803.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
KHV94_RS01530 (330273)330273..330986+714WP_004145133.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
KHV94_RS01535 (331150)331150..331371+222WP_004174006.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
KHV94_RS01540 (331368)331368..331736+369WP_023285605.1type II toxin-antitoxin system death-on-curing family toxinToxin
KHV94_RS01545 (332009)332009..333325+1317WP_002920796.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
KHV94_RS01550 (333432)333432..334319+888WP_002920792.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
KHV94_RS01555 (334316)334316..335161+846WP_004145129.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
KHV94_RS01560 (335163)335163..336233+1071WP_004150074.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--326136..33697010834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13534.89 Da        Isoelectric Point: 8.6410

>T202217 WP_023285605.1 NZ_CP074519:331368-331736 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGITVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T202217 NZ_CP099349:222329-222432 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT202217 WP_004174006.1 NZ_CP074519:331150-331371 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT202217 NZ_CP099349:c222470-222202 [Escherichia fergusonii]
AAAGTCAGCGAATGGAATATTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E5YJY7

References