Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 267628..268285 Replicon chromosome
Accession NZ_CP074448
Organism Enterobacter asburiae strain S3_CRE3

Toxin (Protein)


Gene name higB Uniprot ID A0A808IF03
Locus tag KHV90_RS01225 Protein ID WP_033146338.1
Coordinates 267986..268285 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808ICP3
Locus tag KHV90_RS01220 Protein ID WP_033146339.1
Coordinates 267628..267975 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV90_RS01190 (KHV90_01190) 263044..263778 + 735 WP_048979788.1 class I SAM-dependent methyltransferase -
KHV90_RS01195 (KHV90_01195) 263772..264374 - 603 WP_048979787.1 short chain dehydrogenase -
KHV90_RS01200 (KHV90_01200) 264472..265359 + 888 WP_048979786.1 LysR family transcriptional regulator -
KHV90_RS01205 (KHV90_01205) 265380..266561 + 1182 WP_048979785.1 PLP-dependent aminotransferase family protein -
KHV90_RS01210 (KHV90_01210) 266646..267155 + 510 WP_048979784.1 hypothetical protein -
KHV90_RS01215 (KHV90_01215) 267158..267583 - 426 WP_048979783.1 nucleoside triphosphatase NudI -
KHV90_RS01220 (KHV90_01220) 267628..267975 - 348 WP_033146339.1 HigA family addiction module antitoxin Antitoxin
KHV90_RS01225 (KHV90_01225) 267986..268285 - 300 WP_033146338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHV90_RS01230 (KHV90_01230) 268537..269706 - 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
KHV90_RS01235 (KHV90_01235) 269717..271915 - 2199 WP_048979782.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11691.32 Da        Isoelectric Point: 10.0346

>T202186 WP_033146338.1 NZ_CP074448:c268285-267986 [Enterobacter asburiae]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

>T202186 NZ_CP099338:c2171451-2171173 [Escherichia fergusonii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGTGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATCTCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.02 Da        Isoelectric Point: 7.0134

>AT202186 WP_033146339.1 NZ_CP074448:c267975-267628 [Enterobacter asburiae]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp

>AT202186 NZ_CP099338:c2171173-2170889 [Escherichia fergusonii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAGCTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTTACCGGAAAAGCGGCATTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTAGATGTGTCGCGACTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IF03

Antitoxin

Source ID Structure
AlphaFold DB A0A808ICP3

References