Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1713278..1713924 Replicon chromosome
Accession NZ_CP074437
Organism Klebsiella sp. A52

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KGA69_RS07960 Protein ID WP_213292974.1
Coordinates 1713278..1713625 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KGA69_RS07965 Protein ID WP_045394831.1
Coordinates 1713625..1713924 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGA69_RS07950 (1709162) 1709162..1710595 + 1434 WP_045394829.1 glycogen synthase GlgA -
KGA69_RS07955 (1710613) 1710613..1713060 + 2448 WP_047047942.1 glycogen phosphorylase -
KGA69_RS07960 (1713278) 1713278..1713625 + 348 WP_213292974.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGA69_RS07965 (1713625) 1713625..1713924 + 300 WP_045394831.1 XRE family transcriptional regulator Antitoxin
KGA69_RS07970 (1714269) 1714269..1715777 - 1509 WP_213292976.1 glycerol-3-phosphate dehydrogenase -
KGA69_RS07975 (1715984) 1715984..1716313 + 330 WP_015369349.1 thiosulfate sulfurtransferase GlpE -
KGA69_RS07980 (1716366) 1716366..1717196 + 831 WP_015703685.1 rhomboid family intramembrane serine protease GlpG -
KGA69_RS07985 (1717216) 1717216..1717974 + 759 WP_015369351.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13489.55 Da        Isoelectric Point: 7.2785

>T202140 WP_213292974.1 NZ_CP074437:1713278-1713625 [Klebsiella sp. A52]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKGSKFQNMKELRVQHHGLPVRAFFAFDPLRKAI
VICAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T202140 NZ_CP099327:c3932222-3931812 [Enterobacter ludwigii]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGAGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10782.55 Da        Isoelectric Point: 10.1464

>AT202140 WP_045394831.1 NZ_CP074437:1713625-1713924 [Klebsiella sp. A52]
MGTLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQISQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT202140 NZ_CP099327:c3932469-3932203 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References