Detailed information of TA system TA202130

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4488642..4489244
• Replicon: chromosome
• Accession: NZ_CP074428
• Organism: Salmonella sp. SJTUF14523

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: KFD69_RS21705
• Protein ID: WP_001159635.1
• Coordinates: 4488933..4489244 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KFD69_RS21700
• Protein ID: WP_000362050.1
• Coordinates: 4488642..4488932 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFD69_RS21685 (4486135)	4486135..4487037	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
KFD69_RS21690 (4487034)	4487034..4487669	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
KFD69_RS21695 (4487666)	4487666..4488595	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
KFD69_RS21700 (4488642)	4488642..4488932	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
KFD69_RS21705 (4488933)	4488933..4489244	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
KFD69_RS21710 (4489462)	4489462..4490391	+	930	WP_001127705.1	alpha/beta hydrolase	-
KFD69_RS21715 (4490477)	4490477..4490788	+	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
KFD69_RS21720 (4490785)	4490785..4491231	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
KFD69_RS21725 (4491246)	4491246..4492187	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
KFD69_RS21730 (4492232)	4492232..4492669	-	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
KFD69_RS21735 (4492666)	4492666..4493538	-	873	WP_000921423.1	virulence factor BrkB family protein	-
KFD69_RS21740 (4493532)	4493532..4494131	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T202130 WP_001159635.1 NZ_CP074428:c4489244-4488933 [Salmonella sp. SJTUF14523]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T202130 NZ_CP099323:3489154-3489372 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAGCGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT202130 WP_000362050.1 NZ_CP074428:c4488932-4488642 [Salmonella sp. SJTUF14523]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT202130 NZ_CP099323:3488751-3489125 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGTTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97