Detailed information of TA system TA202100

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 40798..41051
• Replicon: plasmid p15034A
• Accession: NZ_CP074426
• Organism: Salmonella sp. SJTUF15034

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: G9G1E3
• Locus tag: KFD68_RS22885
• Protein ID: WP_001312851.1
• Coordinates: 40902..41051 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	40798..40857 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFD68_RS22860 (37525)	37525..38271	+	747	WP_000205770.1	conjugal transfer pilus acetylase TraX	-
KFD68_RS22865 (38326)	38326..38886	+	561	WP_000139328.1	fertility inhibition protein FinO	-
KFD68_RS22870 (39018)	39018..39218	+	201	WP_015059022.1	hypothetical protein	-
KFD68_RS22875 (39604)	39604..40203	+	600	WP_032083981.1	PIN domain-containing protein	-
KFD68_RS22880 (40265)	40265..40597	+	333	WP_152916585.1	hypothetical protein	-
- (40798)	40798..40857	-	60	NuclAT_1	-	Antitoxin
- (40798)	40798..40857	-	60	NuclAT_1	-	Antitoxin
- (40798)	40798..40857	-	60	NuclAT_1	-	Antitoxin
- (40798)	40798..40857	-	60	NuclAT_1	-	Antitoxin
KFD68_RS22885 (40902)	40902..41051	+	150	WP_001312851.1	Hok/Gef family protein	Toxin
KFD68_RS22890 (41335)	41335..41583	+	249	WP_000083837.1	replication regulatory protein RepA	-
KFD68_RS24110 (41828)	41828..41902	+	75	WP_001375168.1	RepA leader peptide Tap	-
KFD68_RS22900 (41895)	41895..42752	+	858	WP_032495102.1	incFII family plasmid replication initiator RepA	-
KFD68_RS22905 (43691)	43691..44152	+	462	WP_072643484.1	histidine phosphatase family protein	-
KFD68_RS22910 (44308)	44308..45507	-	1200	WP_072648941.1	IS91 family transposase	-
KFD68_RS22915 (45517)	45517..45705	-	189	WP_000957857.1	hypothetical protein	-
KFD68_RS22920 (45799)	45799..46032	+	234	WP_234884845.1	CPBP family intramembrane metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	aph(3')-IIa / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / blaTEM-1B / blaCTX-M-55	-	1..101606	101606

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5542.67 Da
• Isoelectric Point: 8.7678

>T202100 WP_001312851.1 NZ_CP074426:40902-41051 [Salmonella sp. SJTUF15034]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T202100 NZ_CP099314:c2310871-2310386 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAACGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT202100 NZ_CP074426:c40857-40798 [Salmonella sp. SJTUF15034]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A829C8K5

Antitoxin