Detailed information of TA system TA202097

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1320..1589
• Replicon: plasmid p15034A
• Accession: NZ_CP074426
• Organism: Salmonella sp. SJTUF15034

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: KFD68_RS22655
• Protein ID: WP_001372321.1
• Coordinates: 1464..1589 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	1320..1385 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFD68_RS22645	1..435	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
KFD68_RS22650	432..1151	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	1163..1387	+	225	NuclAT_0	-	-
-	1163..1387	+	225	NuclAT_0	-	-
-	1163..1387	+	225	NuclAT_0	-	-
-	1163..1387	+	225	NuclAT_0	-	-
-	1320..1385	-	66	-	-	Antitoxin
KFD68_RS24020	1373..1522	+	150	Protein_2	plasmid maintenance protein Mok	-
KFD68_RS22655	1464..1589	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
KFD68_RS22660	1908..2204	-	297	Protein_4	hypothetical protein	-
KFD68_RS22665	2504..2800	+	297	WP_001272251.1	hypothetical protein	-
KFD68_RS22670	2911..3732	+	822	WP_001234445.1	DUF932 domain-containing protein	-
KFD68_RS22675	4029..4676	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
KFD68_RS22680	4953..5336	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
KFD68_RS22685	5527..6213	+	687	WP_015059009.1	PAS domain-containing protein	-
KFD68_RS22690	6307..6534	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	aph(3')-IIa / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / blaTEM-1B / blaCTX-M-55	-	1..101606	101606

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T202097 WP_001372321.1 NZ_CP074426:1464-1589 [Salmonella sp. SJTUF15034]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T202097 NZ_CP099314:c1092075-1091002 [Enterobacter hormaechei]
ATGACAGTCAGAAGTTATAAGGATTTAAATCTGGTCAGGGCTAACATCGAAACTGAATGCAGGCAGTTCATTCAAACCAG
AACGTATGCAATTCAGTCAATTGGCCCGATGCCGGGGCAAAAACCCGGACTCAGAGTGACATTCGCGAAAACAGGAGAGA
ACTTCGCTACCGTTAACATTTTCTATAACGGCGATGGCTCGTCTACAGTTCAGTATCTTACGGGGGCTAATCAGTCTCTG
GGTAAGGAGCTTGCTGATTACCTTTTTGAAACCATTAACCCTGAAGAATTTGAACATGTAAATATGGTCGTGGAAGGGTT
TGTGGAGGACTCAATTTTTCCTGTGCTTGAGTTATCAGCAGAAGAAACGCATATTGAGTTCTGGGAACACCTTCGTAACA
CTCACTCCATCGTGTGGAAAATCACCTCTACTACCTACCAAGATGAATTGACGGTTACCCTGTACACCACTACAGGCAAG
CTTCAGATTCAAGGACGCCCGCTATCCTGCTATCGGGTTTTTACCTTCAATCTGGCAGAACTGCTTAATTTGCAAGGTCT
GGAAAAAGTGTTGATTCGCCAAGATGATGGCAAAGCGAACATTGTTCAACAGGAAGTAGCCCGCGCTAACCTGGAGTCTA
TAATGGGTGATGCTTATCCTCACTTGCACGTCACTGCTGAAAAATTGCTCATTTCAGGTCTATGTGTTAAGCTTGCCGCC
CCTAAATTGCCAGACTACTGCATGTTGCTTTACCCGGAACTTCGCTCCGTTGAGGGTGTCTTAAAGAATAAAATGTACAC
ATTTGGCATGTCTGTACAGCAACCTTTAGGGTTTGGGCCTTTTTTCGATAAGGTTGGCTTAAATTTCATTTTGAAACCAC
AATATGCGGCTCCTCTCAGGCCAGAGCAGGCTAATGCCATCAATGAAGCCTATACTTTCTGGAATGCGGAACGTCATGCT
GTGTTTCACATGGAAACAGCGGTAGATTCCAGCCGCATGATTTCTGATATGGCCCGACTAATGACCAAAGCCACTAAAGC
GTGGCAAATAATCAAGGATTTGTATCTTGTTTGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT202097 NZ_CP074426:c1385-1320 [Salmonella sp. SJTUF15034]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin