Detailed information of TA system TA202095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4488078..4488680
• Replicon: chromosome
• Accession: NZ_CP074425
• Organism: Salmonella sp. SJTUF15034

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: KFD68_RS21705
• Protein ID: WP_001159635.1
• Coordinates: 4488369..4488680 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KFD68_RS21700
• Protein ID: WP_000362050.1
• Coordinates: 4488078..4488368 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFD68_RS21685 (4485571)	4485571..4486473	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
KFD68_RS21690 (4486470)	4486470..4487105	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
KFD68_RS21695 (4487102)	4487102..4488031	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
KFD68_RS21700 (4488078)	4488078..4488368	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
KFD68_RS21705 (4488369)	4488369..4488680	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
KFD68_RS21710 (4488898)	4488898..4489827	+	930	WP_001127705.1	alpha/beta hydrolase	-
KFD68_RS21715 (4489913)	4489913..4490224	+	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
KFD68_RS21720 (4490221)	4490221..4490667	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
KFD68_RS21725 (4490682)	4490682..4491623	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
KFD68_RS21730 (4491668)	4491668..4492105	-	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
KFD68_RS21735 (4492102)	4492102..4492974	-	873	WP_000921423.1	virulence factor BrkB family protein	-
KFD68_RS21740 (4492968)	4492968..4493567	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T202095 WP_001159635.1 NZ_CP074425:c4488680-4488369 [Salmonella sp. SJTUF15034]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T202095 NZ_CP099311:4258973-4259350 [Enterobacter ludwigii]
ATGAAAACACAATCAGCCTCCGCCACGCGGGCGGCTCCGTCACGCCCGTCCCCCGTTGAAATCTGGCAGCAGCTCCTGAG
CCACCTGCTGGACCAGCACTATGGCCTCACGCTTAACGACACGCCCTTTGGCAACGACAGCGTCATTCAGGAACATATCG
ACGCAGGGATCTCCCTGTGCGACGCCGTGAATTTTATCGTGGAAAAGTACGATCTGGTACGTACCGATCGCCGCGGTTTC
AGTGCAGAAACACAGTCACCGCTTATCGGCAGTATCGATATTCTGCGGGCCAGGAAGGCGACCGGGCTGATGACCCGTCA
TAGCTACAGGGCCGTTACCGACATCACCACCGGCAAATACCGTGGGGTGCAGCAATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT202095 WP_000362050.1 NZ_CP074425:c4488368-4488078 [Salmonella sp. SJTUF15034]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT202095 NZ_CP099311:4258589-4258948 [Enterobacter ludwigii]
TTGTCGAATAAAACACGACCAGACAGCCACGATATCGCCGACCCCTGGTGGGGGCTTAAACGCAATATCACACCCTGTTT
TGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCTGCATTACCTGAACGACCGCGCCAGCATCACCGGCACCTTCACCGACG
CGGATTTATGCCATCTCGACCAGGCGTTTCCGCTGCTTTTGAAACAGCTCGAGCTGATGCTCACCAGCGGTGAACTTAAC
CCCCGCCATCAGCATTGCGTCACCCTGTATGCAAAAGGGCTTACCTGCGAGGCCGATAGCCTCGGCTCGAACGGGTACAT
CTATCTCGTAATTTACCCAACGCCAGCAACCGCCGCATAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97