Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 600546..601345 | Replicon | chromosome |
| Accession | NZ_CP074366 | ||
| Organism | Escherichia coli strain ZYB62 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | F4VJD3 |
| Locus tag | KG092_RS02920 | Protein ID | WP_000347266.1 |
| Coordinates | 600546..601010 (-) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | S1EB98 |
| Locus tag | KG092_RS02925 | Protein ID | WP_001307405.1 |
| Coordinates | 601010..601345 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KG092_RS02890 (595547) | 595547..595981 | - | 435 | WP_000948824.1 | PTS galactosamine/N-acetylgalactosamine transporter subunit IIA | - |
| KG092_RS02895 (595999) | 595999..596877 | - | 879 | WP_001315856.1 | PTS N-acetylgalactosamine transporter subunit IID | - |
| KG092_RS02900 (596867) | 596867..597646 | - | 780 | WP_000406214.1 | PTS N-acetylgalactosamine transporter subunit IIC | - |
| KG092_RS02905 (597657) | 597657..598130 | - | 474 | WP_001295547.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
| KG092_RS02910 (598153) | 598153..599433 | - | 1281 | WP_000681921.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
| KG092_RS02915 (599682) | 599682..600491 | + | 810 | WP_000072187.1 | aga operon transcriptional regulator AgaR | - |
| KG092_RS02920 (600546) | 600546..601010 | - | 465 | WP_000347266.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
| KG092_RS02925 (601010) | 601010..601345 | - | 336 | WP_001307405.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
| KG092_RS02930 (601494) | 601494..603065 | - | 1572 | WP_001273741.1 | galactarate dehydratase | - |
| KG092_RS02935 (603440) | 603440..604774 | + | 1335 | WP_000599636.1 | galactarate/glucarate/glycerate transporter GarP | - |
| KG092_RS02940 (604790) | 604790..605560 | + | 771 | WP_001058227.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 600546..612333 | 11787 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17841.18 Da Isoelectric Point: 9.4947
>T201965 WP_000347266.1 NZ_CP074366:c601010-600546 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH
Download Length: 465 bp
>T201965 NZ_CP099217:c787312-786935 [Citrobacter freundii]
ATGCAAACACAACCCGTATCCCCGGCACGGGAGGCTTCTCCACGTCTGTCACCCGTGGAGATTTGGCAGCGACTTCTGAG
CCACCTGCTGGATCATCACTACGGTCTGGCGCTAAACGACACGCCGTTTGGCAACGACGACGTGATTCAGGAGCACATTG
ACGCCGGTATTTCCCTGTGTGATGCCGTCAATTTTATCGTCGAAAAATACGATCTGGTACGCACTGACCGTTACGGATCC
AGCACTACAGAGCAGTCACCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGTAAGGCCTGTGGACTGATGACACGTAA
CGGCTACAGAGCGGTGACAGATATCACTACAGGCAAATACAGCAAGATGACCCGATGA
ATGCAAACACAACCCGTATCCCCGGCACGGGAGGCTTCTCCACGTCTGTCACCCGTGGAGATTTGGCAGCGACTTCTGAG
CCACCTGCTGGATCATCACTACGGTCTGGCGCTAAACGACACGCCGTTTGGCAACGACGACGTGATTCAGGAGCACATTG
ACGCCGGTATTTCCCTGTGTGATGCCGTCAATTTTATCGTCGAAAAATACGATCTGGTACGCACTGACCGTTACGGATCC
AGCACTACAGAGCAGTCACCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGTAAGGCCTGTGGACTGATGACACGTAA
CGGCTACAGAGCGGTGACAGATATCACTACAGGCAAATACAGCAAGATGACCCGATGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12358.94 Da Isoelectric Point: 4.8616
>AT201965 WP_001307405.1 NZ_CP074366:c601345-601010 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT201965 NZ_CP099217:c787720-787361 [Citrobacter freundii]
TTGTTGAATAAAACACTGCCGGCAAATCATCATATTTCTGAACCGTGGTGGGGACTGAAACGTAATATCACCCCGTGCTT
CGGTGCACGGCTGGTACAGGAAGGCAACCGGCTGCATTATCTGGCCGACCGCGCCAGCATCACCGGGACATTCACCGACG
CGGATTTGCGCCATCTCGACCAAGCGTTTCCGGTACTGCTGAAGCAAATGGAACTGATGCTGGTTTCCGGCGAACTCAGT
CCCCGCCATCAGCACTGCGTCACGCTGTATGCAAAGGGACTGACCTGCGAGGCTGACTCACTCGGATCGCATGGCTATAT
CTATATAGCGATTTATCCGACACCATCAGTAACGTCATAA
TTGTTGAATAAAACACTGCCGGCAAATCATCATATTTCTGAACCGTGGTGGGGACTGAAACGTAATATCACCCCGTGCTT
CGGTGCACGGCTGGTACAGGAAGGCAACCGGCTGCATTATCTGGCCGACCGCGCCAGCATCACCGGGACATTCACCGACG
CGGATTTGCGCCATCTCGACCAAGCGTTTCCGGTACTGCTGAAGCAAATGGAACTGATGCTGGTTTCCGGCGAACTCAGT
CCCCGCCATCAGCACTGCGTCACGCTGTATGCAAAGGGACTGACCTGCGAGGCTGACTCACTCGGATCGCATGGCTATAT
CTATATAGCGATTTATCCGACACCATCAGTAACGTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A836NGD2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XVC7 |