Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2397444..2398082 Replicon chromosome
Accession NZ_CP074359
Organism Escherichia coli strain XJ6.2

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag KFQ22_RS11625 Protein ID WP_001447010.1
Coordinates 2397906..2398082 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KFQ22_RS11620 Protein ID WP_001270286.1
Coordinates 2397444..2397860 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ22_RS11600 (2392596) 2392596..2393537 - 942 WP_001251304.1 ABC transporter permease -
KFQ22_RS11605 (2393538) 2393538..2394551 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
KFQ22_RS11610 (2394569) 2394569..2395714 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
KFQ22_RS11615 (2395959) 2395959..2397365 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
KFQ22_RS11620 (2397444) 2397444..2397860 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KFQ22_RS11625 (2397906) 2397906..2398082 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KFQ22_RS11630 (2398304) 2398304..2398534 + 231 WP_000494244.1 YncJ family protein -
KFQ22_RS11635 (2398626) 2398626..2400587 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KFQ22_RS11640 (2400660) 2400660..2401196 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KFQ22_RS11645 (2401288) 2401288..2402463 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2402503..2403651 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T201940 WP_001447010.1 NZ_CP074359:c2398082-2397906 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T201940 NZ_CP099084:c4653003-4652629 [Citrobacter freundii]
ATGGTTAACGGGTCAGCGCTTTTTGATACCAATATCCTCATCGATCTGTTTAGCGGACGGGCTGAAGCAAAATATGCGAT
AGAAACATGGCCGCCGCAGAATGCCATTAGCCTTATCACGTGGATGGAGGTAATGGTAGGCGCAAAAAAGTATCGTCAGG
AATCCCGTACACGTGTTGCGTTGAGTGCATTTAACATTATCGGCGTGTCGCAGGATATTGCGGAAAGAAGCGTTCGCCTC
AGGCAGGAATATGGGATGAAATTGCCGGATGCGATTATTCTGGCAACTGCGCAGATACATCGCCTTACGCTGGTCACGCG
TAATACCAAGGATTTTGCAGAAATTCCTGGGGTAATCACGCCATATCAAGAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT201940 WP_001270286.1 NZ_CP074359:c2397860-2397444 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT201940 NZ_CP099084:c4653227-4653003 [Citrobacter freundii]
ATGGGCAGAATTTTACTCGATTTGTCTGATGAGGTGATTCAACGGCTTGACGATCTCAAGGTGCAGCGCAATCTTCCCCG
TGCTGAATTACTACGGGAAGCGGTTGAGCAGTATCTGGAAAGGCAGGATAACGCTGAGACCACTATTTCTGGCGCCCTTG
GTCTATGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGCAAGCTTCGTGAGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References