Detailed information of TA system TA201940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2397444..2398082
• Replicon: chromosome
• Accession: NZ_CP074359
• Organism: Escherichia coli strain XJ6.2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0A6TXU8
• Locus tag: KFQ22_RS11625
• Protein ID: WP_001447010.1
• Coordinates: 2397906..2398082 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KFQ22_RS11620
• Protein ID: WP_001270286.1
• Coordinates: 2397444..2397860 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFQ22_RS11600 (2392596)	2392596..2393537	-	942	WP_001251304.1	ABC transporter permease	-
KFQ22_RS11605 (2393538)	2393538..2394551	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
KFQ22_RS11610 (2394569)	2394569..2395714	-	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
KFQ22_RS11615 (2395959)	2395959..2397365	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
KFQ22_RS11620 (2397444)	2397444..2397860	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
KFQ22_RS11625 (2397906)	2397906..2398082	-	177	WP_001447010.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
KFQ22_RS11630 (2398304)	2398304..2398534	+	231	WP_000494244.1	YncJ family protein	-
KFQ22_RS11635 (2398626)	2398626..2400587	-	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
KFQ22_RS11640 (2400660)	2400660..2401196	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
KFQ22_RS11645 (2401288)	2401288..2402463	+	1176	WP_001236265.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP020543 Escherichia coli C IS/Tn TA075073 2433298..2434446 0.008	flank	IS/Tn	-	-	2402503..2403651	1148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6779.86 Da
• Isoelectric Point: 11.2298

>T201940 WP_001447010.1 NZ_CP074359:c2398082-2397906 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T201940 NZ_CP099084:c4653003-4652629 [Citrobacter freundii]
ATGGTTAACGGGTCAGCGCTTTTTGATACCAATATCCTCATCGATCTGTTTAGCGGACGGGCTGAAGCAAAATATGCGAT
AGAAACATGGCCGCCGCAGAATGCCATTAGCCTTATCACGTGGATGGAGGTAATGGTAGGCGCAAAAAAGTATCGTCAGG
AATCCCGTACACGTGTTGCGTTGAGTGCATTTAACATTATCGGCGTGTCGCAGGATATTGCGGAAAGAAGCGTTCGCCTC
AGGCAGGAATATGGGATGAAATTGCCGGATGCGATTATTCTGGCAACTGCGCAGATACATCGCCTTACGCTGGTCACGCG
TAATACCAAGGATTTTGCAGAAATTCCTGGGGTAATCACGCCATATCAAGAGTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT201940 WP_001270286.1 NZ_CP074359:c2397860-2397444 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT201940 NZ_CP099084:c4653227-4653003 [Citrobacter freundii]
ATGGGCAGAATTTTACTCGATTTGTCTGATGAGGTGATTCAACGGCTTGACGATCTCAAGGTGCAGCGCAATCTTCCCCG
TGCTGAATTACTACGGGAAGCGGTTGAGCAGTATCTGGAAAGGCAGGATAACGCTGAGACCACTATTTCTGGCGCCCTTG
GTCTATGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGCAAGCTTCGTGAGGAATGGTAA

Structures

Toxin

• AlphaFold DB: A0A0A6TXU8