Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1754660..1755162 | Replicon | chromosome |
| Accession | NZ_CP074359 | ||
| Organism | Escherichia coli strain XJ6.2 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A7I6H4L3 |
| Locus tag | KFQ22_RS08365 | Protein ID | WP_000767831.1 |
| Coordinates | 1754908..1755162 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | KFQ22_RS08360 | Protein ID | WP_001259255.1 |
| Coordinates | 1754660..1754911 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFQ22_RS08335 (1749837) | 1749837..1750904 | - | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| KFQ22_RS08340 (1750904) | 1750904..1751974 | - | 1071 | WP_000108939.1 | histidinol-phosphate transaminase | - |
| KFQ22_RS08345 (1751971) | 1751971..1753275 | - | 1305 | WP_001375298.1 | histidinol dehydrogenase | - |
| KFQ22_RS08350 (1753281) | 1753281..1754180 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| KFQ22_RS08355 (1754326) | 1754326..1754376 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| KFQ22_RS08360 (1754660) | 1754660..1754911 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| KFQ22_RS08365 (1754908) | 1754908..1755162 | + | 255 | WP_000767831.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| KFQ22_RS08370 (1755245) | 1755245..1756069 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| KFQ22_RS08375 (1756115) | 1756115..1757044 | + | 930 | WP_048217808.1 | LysR substrate-binding domain-containing protein | - |
| KFQ22_RS08380 (1757259) | 1757259..1757321 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| KFQ22_RS08385 (1757311) | 1757311..1758669 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| KFQ22_RS08390 (1758848) | 1758848..1759906 | + | 1059 | WP_048217810.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| KFQ22_RS08395 (1759920) | 1759920..1760147 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10231.67 Da Isoelectric Point: 8.8202
>T201928 WP_000767831.1 NZ_CP074359:1754908-1755162 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY
Download Length: 255 bp
>T201928 NZ_CP099084:458454-458942 [Citrobacter freundii]
ATGATCTCCGCCCCTGAGCCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGCGTGGATTCTATGGATAACTG
GCTGAAACAACGGGCGATGAAGAACCAGCTTTCCGGCGCATCCCGCACGTTTGTCTGCTGCGATGATGTTAAGGTGATGG
CTTACTACTCGCTGGCATCCAGCGCCGTAACGACAAATACGGCACCCGGTCGTTTTCGCCGTAATATGCCTGATCCAATC
CCGGTGGTGGTGCTGGGGCGTCTGGCGGTGGATAAGTCGTTGCACGGGCAGGGCTTAGGGCGGGCGTTGATGAGGGATGC
CGGGCTACGGGTAATTCAGGTGGCGGAGACTATCGGCATTCGCGGAATGCTGGTTCATGCCTTGTCGGATGAAGCGCGGG
AGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCAATGGACCCGCTGATGCTGATGGTGACGCTGGGGGATTTGGTGGGA
AGTGTTTGA
ATGATCTCCGCCCCTGAGCCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGCGTGGATTCTATGGATAACTG
GCTGAAACAACGGGCGATGAAGAACCAGCTTTCCGGCGCATCCCGCACGTTTGTCTGCTGCGATGATGTTAAGGTGATGG
CTTACTACTCGCTGGCATCCAGCGCCGTAACGACAAATACGGCACCCGGTCGTTTTCGCCGTAATATGCCTGATCCAATC
CCGGTGGTGGTGCTGGGGCGTCTGGCGGTGGATAAGTCGTTGCACGGGCAGGGCTTAGGGCGGGCGTTGATGAGGGATGC
CGGGCTACGGGTAATTCAGGTGGCGGAGACTATCGGCATTCGCGGAATGCTGGTTCATGCCTTGTCGGATGAAGCGCGGG
AGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCAATGGACCCGCTGATGCTGATGGTGACGCTGGGGGATTTGGTGGGA
AGTGTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT201928 WP_001259255.1 NZ_CP074359:1754660-1754911 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT201928 NZ_CP099084:458164-458457 [Citrobacter freundii]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACTCTGAACCTGCGCATCAAGCCCGCTGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGTTGGAAGCTGCCCGCGCCGCCGCAGAGGAAGCGCTGA
TCGAACAACGTATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTGACTCGTCTGGATCAGGCTCCTGCGCCTAAT
GCCGCACTGCGTAAAACAATGCAGACTCCTGCGCCGTGGGAACAGGAAAAATGA
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACTCTGAACCTGCGCATCAAGCCCGCTGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGTTGGAAGCTGCCCGCGCCGCCGCAGAGGAAGCGCTGA
TCGAACAACGTATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTGACTCGTCTGGATCAGGCTCCTGCGCCTAAT
GCCGCACTGCGTAAAACAATGCAGACTCCTGCGCCGTGGGAACAGGAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7I6H4L3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LNR0 |