Detailed information of TA system TA201885

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3862901..3863159
• Replicon: chromosome
• Accession: NZ_CP074354
• Organism: Escherichia coli strain XJ5.2

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: KFQ11_RS19160
• Protein ID: WP_000809168.1
• Coordinates: 3863007..3863159 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3862901..3862958 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFQ11_RS19130	3858422..3858640	-	219	WP_001300728.1	DUF2575 family protein	-
KFQ11_RS19135	3858743..3859006	+	264	WP_001274021.1	30S ribosomal protein S20	-
KFQ11_RS19140	3859313..3860010	+	698	WP_151351650.1	IS1-like element IS1A family transposase	-
KFQ11_RS19145	3860025..3860252	+	228	Protein_3749	fimbrial family protein	-
KFQ11_RS19150	3860290..3861189	-	900	WP_001338226.1	transcriptional activator NhaR	-
KFQ11_RS19155	3861255..3862421	-	1167	WP_000681362.1	Na+/H+ antiporter NhaA	-
-	3862901..3862958	-	58	-	-	Antitoxin
KFQ11_RS19160	3863007..3863159	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
KFQ11_RS19165	3863237..3864349	+	1113	WP_282318038.1	IS4-like element IS421 family transposase	-
KFQ11_RS19170	3864612..3865742	-	1131	WP_001118475.1	molecular chaperone DnaJ	-
KFQ11_RS19175	3865831..3867747	-	1917	WP_000516135.1	molecular chaperone DnaK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	3859507..3864512	5005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T201885 WP_000809168.1 NZ_CP074354:3863007-3863159 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T201885 NZ_CP098831:c980127-979600 [Salmonella enterica subsp. enterica serovar Indiana]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTAGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT201885 NZ_CP074354:c3862958-3862901 [Escherichia coli]
GTTCAGCATATAGGAGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin