Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 700351..701044 Replicon chromosome
Accession NZ_CP074354
Organism Escherichia coli strain XJ5.2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KFQ11_RS03535 Protein ID WP_000415584.1
Coordinates 700351..700647 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KFQ11_RS03540 Protein ID WP_000650107.1
Coordinates 700649..701044 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ11_RS03500 (695439) 695439..695753 - 315 WP_000958598.1 putative quinol monooxygenase -
KFQ11_RS03505 (695784) 695784..696365 - 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
KFQ11_RS03510 (696684) 696684..697016 + 333 WP_000917684.1 DUF2645 family protein -
KFQ11_RS03515 (697062) 697062..698411 - 1350 WP_282318386.1 quorum sensing histidine kinase QseC -
KFQ11_RS03520 (698408) 698408..699067 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KFQ11_RS03525 (699219) 699219..699611 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KFQ11_RS03530 (699664) 699664..700146 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KFQ11_RS03535 (700351) 700351..700647 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KFQ11_RS03540 (700649) 700649..701044 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KFQ11_RS03545 (701177) 701177..702784 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KFQ11_RS03550 (702922) 702922..705180 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T201869 WP_000415584.1 NZ_CP074354:700351-700647 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T201869 NZ_CP098809:c758896-758603 [Ensifer adhaerens]
ATGGCGTTTCGGCTTTCCGTCGCGGCAGAAGAAGACATCATCGCGATCGCCGCAGATGGGGTGCGCCTTTTCGGCTCCGC
CCAGGCGCGGCGATATCACGATGAACTCTTCGCCGTATTCGCCTTGATTGCCGCCAACCCGCGCATGGCGCGCGAACGCA
CGGAGCTGTCGCCGCCGATGCGCATCCATCCGTTCAAGGCGCATCTGGTCGTCTACCGGGTCGAGGCGGACGGCGACATC
CTCGTCGTTCGCGTCCGTCATGGGCATGAGGACTGGATCAGCAACGCATTTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT201869 WP_000650107.1 NZ_CP074354:700649-701044 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT201869 NZ_CP098809:c759144-758896 [Ensifer adhaerens]
ATGGCGACGATGAACGTATCCTTGCCCGACCCGATGAAGGATTGGGTGGAAGCGCAAACGCGCACGGGCCGTTATGCCAA
CGCCAGCGATTATGTGCGCGACCTCATCCGCAGGGATCAGGAGCGAAATGACAAGGTTGCGGTGATGCAACGCTTTGTCG
ACGACGGTCTGAAGAGCGGCGTCGGGTCCCGCTCCAAGGACGAGCTCTTTTCCGCGGCGCTTACGCGCGCTGAAGTGCCG
CGCGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References