Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 164447..165801 Replicon chromosome
Accession NZ_CP074352
Organism Siccibacter colletis strain YSD YN2

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag KFZ77_RS00810 Protein ID WP_264385196.1
Coordinates 164758..165801 (+) Length 348 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag KFZ77_RS00805 Protein ID WP_264385195.1
Coordinates 164447..164758 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ77_RS00780 (KFZ77_00785) 159944..160963 + 1020 WP_031522002.1 dipeptide ABC transporter permease DppB -
KFZ77_RS00785 (KFZ77_00790) 160973..161875 + 903 WP_264385192.1 dipeptide ABC transporter permease DppC -
KFZ77_RS00790 (KFZ77_00795) 161887..162879 + 993 WP_264385193.1 dipeptide ABC transporter ATP-binding protein -
KFZ77_RS00795 (KFZ77_00800) 162866..163882 + 1017 WP_031521997.1 peptide ABC transporter ATP-binding protein -
KFZ77_RS00800 (KFZ77_00805) 164205..164462 + 258 WP_264385194.1 helix-turn-helix domain-containing protein -
KFZ77_RS00805 (KFZ77_00810) 164447..164758 + 312 WP_264385195.1 HipA N-terminal domain-containing protein Antitoxin
KFZ77_RS00810 (KFZ77_00815) 164758..165801 + 1044 WP_264385196.1 HipA domain-containing protein Toxin
KFZ77_RS00815 (KFZ77_00820) 165878..166063 - 186 WP_264385197.1 toxin-antitoxin system HicB family antitoxin -
KFZ77_RS00820 (KFZ77_00825) 166232..166636 - 405 WP_031521986.1 tRNA(fMet)-specific endonuclease VapC -
KFZ77_RS00825 (KFZ77_00830) 166636..166866 - 231 WP_031521984.1 type II toxin-antitoxin system VapB family antitoxin -
KFZ77_RS00830 (KFZ77_00835) 167050..168735 - 1686 WP_031521983.1 cellulose biosynthesis protein BcsG -
KFZ77_RS00835 (KFZ77_00840) 168728..168922 - 195 WP_031521981.1 cellulose biosynthesis protein BcsF -
KFZ77_RS00840 (KFZ77_00845) 168919..170484 - 1566 WP_264385198.1 cellulose biosynthesis protein BcsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-301)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 348 a.a.        Molecular weight: 38745.57 Da        Isoelectric Point: 5.7562

>T201854 WP_264385196.1 NZ_CP074352:164758-165801 [Siccibacter colletis]
MALCRILLTPLNARDEATGYSARGLKRLTGTGRASPQLPFTRNEFISELPKAQAGMSISGYQPKLQMIVEKGVFNVVEHQ
GEYILKPSPAEFPFLAENEHATMTLMARLGFDVPPHGLVRFTKAQPGDPEEYAFVIRRYDRDEQGNALHQEQLDAAMDIG
EKYGKTAADGKQYVSYERLATFLLANVNDNLAFKIDLFRRIAYAYLLGNNDMHLRNFGLILPPLGKPELAPIYDFVSVAP
YPPVFNSGFLALPLLRCEEGDGELAPGMKTQYGEYLGKDFLVLGEAMGLAKPVVLRLFAQMQSEARTVEAVYRASFMPAG
DSERVLQCYQQRLKRMMNVDEAEMVGT

Download         Length: 1044 bp

>T201854 NZ_CP098801:233021-233548 [Rhizobium anhuiense bv. trifolii]
ATGACTTTACCTGCATGGCATGAGGAACCGATCGCCAAGTCTCACGGTCGGGCGGCCTTCGATTGCGGCGACGCTCAGAT
GAACGAGTTCCTGCTCCGCTTTGCCCGACAAAGCCATGAGCAGAATGCCTCGAAGACCTTCTGTGCTATCGACGACGCAG
TGCGCGACCGCATTCTTGGGTTCTATACAATCGCGCCTTCGGCAGTCGAGCACGCAACTGTGCCTGATGCAATGACACGC
GGTCTTGCCCGCCATGATGTGCCGGGCTTCAAGCTCGCGCGATTGGCTACCGACCGAGCGGTTTCCGGACAGGGACTGGG
AGGCCAGCTCCTAGCTGCCGCAGCGCTCCGCTGCCTACGACTTGCAGGAGAGGGCGGGGGACTTCTATTGATCATCGATG
CCAAAGGCGAGCGCGCCGCCAACTGGTACGCTTCCTATGGCGCCGAACCGCTGAAGGACAAGCCGCTGACTCTCGTGATG
CCGCTCATCACCTTCGCGGCCGACTTGCGGGCTAAACGTCTTCTTTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11718.48 Da        Isoelectric Point: 7.3568

>AT201854 WP_264385195.1 NZ_CP074352:164447-164758 [Siccibacter colletis]
MLRRVTVRLYGEPVGVLEQSDAGFCFTYHADYQGPPLSLSLPVSQRRFPRATLHPFFVSLAPEGWLKRRYSQIQHLDEKD
LLGMLIHNGKNLIGAVQIEPEEA

Download         Length: 312 bp

>AT201854 NZ_CP098801:232746-233024 [Rhizobium anhuiense bv. trifolii]
ATGCCGAGTATAGCGAACGAGAACAGTGAGCGTATGAGTTTGAGGGTGCCTGCCACGGCCAAGGCTAAGCTCGTGCGCGC
TGCGGCACTTCGTAATACCGATCTGACGAATTTCGTAACCCAATCCGCACTGCGAGAAGCAGAAGCTGTGATCGAAGAAG
CCGAAACGATCAAAGTGTCAGAGCGCGATCATCTTCGCATTCTTGAGCTTCTGGAAAATCCGCCCAAACCCAACGCCAAG
CTGCGCGCGGCGATTGCCGGTTTGCCGGACAGCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References