201845

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3739060..3739645 Replicon chromosome
Accession NZ_CP074350
Organism Pantoea dispersa strain YSD_J2

Toxin (Protein)


Gene name higB Uniprot ID U3TYM8
Locus tag KFZ74_RS17670 Protein ID WP_010615566.1
Coordinates 3739346..3739645 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8E1RX80
Locus tag KFZ74_RS17665 Protein ID WP_058774900.1
Coordinates 3739060..3739359 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ74_RS17645 (KFZ74_17615) 3735061..3736362 + 1302 WP_058759604.1 anaerobic C4-dicarboxylate transporter -
KFZ74_RS17650 (KFZ74_17620) 3736449..3738146 + 1698 WP_238561226.1 protein-disulfide reductase DsbD -
KFZ74_RS17655 (KFZ74_17625) 3738213..3738791 + 579 WP_238561227.1 transcriptional regulator -
KFZ74_RS17665 (KFZ74_17635) 3739060..3739359 - 300 WP_058774900.1 helix-turn-helix transcriptional regulator Antitoxin
KFZ74_RS17670 3739346..3739645 - 300 WP_010615566.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFZ74_RS17675 (KFZ74_17645) 3740117..3740365 + 249 Protein_3450 LysR family transcriptional regulator -
KFZ74_RS17680 (KFZ74_17650) 3740466..3741635 - 1170 WP_238561228.1 Gfo/Idh/MocA family oxidoreductase -
KFZ74_RS17685 (KFZ74_17655) 3741646..3742569 - 924 WP_021507774.1 TIM barrel protein -
KFZ74_RS17690 (KFZ74_17660) 3742568..3742756 + 189 WP_058770055.1 hypothetical protein -
KFZ74_RS17695 (KFZ74_17665) 3742769..3743788 - 1020 WP_058770054.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(4-87)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-88)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11308.01 Da        Isoelectric Point: 10.2176

>T201845 WP_010615566.1 NZ_CP074350:c3739645-3739346 [Pantoea dispersa]
MIEDVLASLAVLREFGPTLGRPDVDTLVGSRFSNMKELRVQSNGRAIRAFFAFDPVRRAIVLCAGNKTGTHQRRFYQAMI
KLADREYQQHLEEMNHAKT

Download         Length: 300 bp

>T201845 NZ_CP098792:c86925-86605 [Acinetobacter baumannii]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10921.75 Da        Isoelectric Point: 9.7643

>AT201845 WP_058774900.1 NZ_CP074350:c3739359-3739060 [Pantoea dispersa]
MPKLEDLIAQRSPESQARIRNKAAEKIIEIRLRQLREELALSQVQLAEKMGVSQPAIAAIEARGDELKLSSLKKYVEALG
GKLSVTVELPAGDGRIFQL

Download         Length: 300 bp

>AT201845 NZ_CP098792:c86612-86340 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References