Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4449242..4449972 Replicon chromosome
Accession NZ_CP074347
Organism Serratia entomophila strain 626

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KFQ06_RS21110 Protein ID WP_234591346.1
Coordinates 4449242..4449553 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KFQ06_RS21115 Protein ID WP_234586471.1
Coordinates 4449550..4449972 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ06_RS21080 (KFQ06_21085) 4444598..4445323 + 726 WP_234586462.1 LPS export ABC transporter ATP-binding protein -
KFQ06_RS21085 (KFQ06_21090) 4445374..4446807 + 1434 WP_252961068.1 RNA polymerase factor sigma-54 -
KFQ06_RS21090 (KFQ06_21095) 4446831..4447118 + 288 WP_004937038.1 ribosome hibernation promoting factor -
KFQ06_RS21095 (KFQ06_21100) 4447278..4447739 + 462 WP_252961069.1 PTS IIA-like nitrogen regulatory protein PtsN -
KFQ06_RS21100 (KFQ06_21105) 4447871..4448725 + 855 WP_234586468.1 RNase adapter RapZ -
KFQ06_RS21105 (KFQ06_21110) 4448722..4448994 + 273 WP_234586470.1 PTS phosphocarrier protein NPr -
KFQ06_RS21110 (KFQ06_21115) 4449242..4449553 + 312 WP_234591346.1 type II toxin-antitoxin system HigB family toxin Toxin
KFQ06_RS21115 (KFQ06_21120) 4449550..4449972 + 423 WP_234586471.1 helix-turn-helix domain-containing protein Antitoxin
KFQ06_RS21120 (KFQ06_21125) 4450055..4450450 - 396 WP_095099419.1 hypothetical protein -
KFQ06_RS21125 (KFQ06_21130) 4450472..4451545 - 1074 WP_231922104.1 hypothetical protein -
KFQ06_RS21130 (KFQ06_21135) 4451608..4453524 - 1917 WP_252961070.1 PRD domain-containing protein -
KFQ06_RS21135 (KFQ06_21140) 4453575..4454789 - 1215 WP_252961071.1 lactonase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(2-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12253.09 Da        Isoelectric Point: 9.3944

>T201834 WP_234591346.1 NZ_CP074347:4449242-4449553 [Serratia entomophila]
MHIISREPFNHAAKQYPNEEAALDAVYKTLRRGSFNTPDDLKALFPSLDRMKYRAKWWVIDIGGNNLRMLFFASFDTQKI
FVKHIVCHAEYDKLMQLYQRNQE

Download         Length: 312 bp

>T201834 NZ_CP098778:1185280-1185561 [Enterobacter hormaechei]
TTGCCTGCGGGAGTACAGGCTAAGCTGATTCGCCAGCTTGATAAATTACGCAACAACCCGACAGTATTGCGTGAACCTGA
CAGCAAACCCTTACCCAATGGTTTGTTCGAAATCCGAACCGTCGGGCTGATCCATACTCGTGGGATCTACGTTTATCAGC
GGGAAAGAACCATTTTTCTGCTGCGGGTGTTTATCAAGAAGACGCAAAAAACGCCCTCTGCTGAACTCCGTCTGGCACTG
AAACGACAACAGGAGATGTTGGATGAGCAAAAAGATTATTGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15810.15 Da        Isoelectric Point: 5.2453

>AT201834 WP_234586471.1 NZ_CP074347:4449550-4449972 [Serratia entomophila]
MISDAIKATQELLRAVPLLRGSTSQQDYREALELVEHLLETDEHNPLIDLLAAKIAEFEESSPDFAEFNLRQRQLPQGVA
ALSVLMEQHQLSQRDFENEIGKKSLVSQILNGKRSLTIPHIMALAKRFNLPPAIFLPEAR

Download         Length: 423 bp

>AT201834 NZ_CP098778:1185542-1185829 [Enterobacter hormaechei]
ATGAGCAAAAAGATTATTGACTGGGACGAACTCAGAGCTGAACTGTTAAGCGATTCAGAAGTCCAGGCTTCCTTTGATGC
AGAAGAGCGCAAGGAACGCCTGCGGGAGATGCTGGCGCAATGGCGCAATCATGCTGGTCTGACGCGCGCCCAGGTGGCGG
AGCGGATGGGCGTCAGCGCACCGACGGTATCACGAATGGAAGCAAATATTACCCGGGCGAGTCTCGATACATTAACGCGT
TATGCGCTGGTGTGCGGGGTAAAGCATCCGCAGATAACGCTTTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References