Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4393399..4394027 Replicon chromosome
Accession NZ_CP074347
Organism Serratia entomophila strain 626

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KFQ06_RS20800 Protein ID WP_234586408.1
Coordinates 4393399..4393689 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KFQ06_RS20805 Protein ID WP_234586409.1
Coordinates 4393704..4394027 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ06_RS20790 (KFQ06_20795) 4389977..4391998 + 2022 WP_252961059.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
KFQ06_RS20795 (KFQ06_20800) 4392028..4393167 - 1140 WP_234586407.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
KFQ06_RS20800 (KFQ06_20805) 4393399..4393689 + 291 WP_234586408.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFQ06_RS20805 (KFQ06_20810) 4393704..4394027 + 324 WP_234586409.1 HigA family addiction module antitoxin Antitoxin
KFQ06_RS20810 (KFQ06_20815) 4394020..4394532 + 513 WP_234586410.1 M48 family metallopeptidase -
KFQ06_RS20815 (KFQ06_20820) 4394586..4395566 + 981 WP_252961060.1 Gfo/Idh/MocA family oxidoreductase -
KFQ06_RS20820 (KFQ06_20825) 4395568..4396299 + 732 WP_234586412.1 glutamine amidotransferase -
KFQ06_RS20825 (KFQ06_20830) 4396680..4397654 + 975 WP_272496160.1 TerC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11672.33 Da        Isoelectric Point: 10.5709

>T201833 WP_234586408.1 NZ_CP074347:4393399-4393689 [Serratia entomophila]
MIKSFRDRYLQQFYLEGRRSRLIPGVLERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAADRVYLDPHQDT

Download         Length: 291 bp

>T201833 NZ_CP098778:c1096138-1095920 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACTCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12140.80 Da        Isoelectric Point: 6.7201

>AT201833 WP_234586409.1 NZ_CP074347:4393704-4394027 [Serratia entomophila]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQANAQRVRLRPIKEILGRNITHA

Download         Length: 324 bp

>AT201833 NZ_CP098778:c1096540-1096166 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References