Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4200487..4201147 Replicon chromosome
Accession NZ_CP074177
Organism Enterobacter asburiae strain JBIWA002

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KGP20_RS20655 Protein ID WP_223604394.1
Coordinates 4200794..4201147 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1Z3MX79
Locus tag KGP20_RS20650 Protein ID WP_029741460.1
Coordinates 4200487..4200789 (-) Length 101 a.a.

Genomic Context


KGP20_RS20630KGP20_RS20645KGP20_RS20665KGP20_RS20640KGP20_RS20650KGP20_RS20655KGP20_RS20660KGP20_RS20670KGP20_RS20675
Location: 4196447..4198636 (2190 bp)
Type: Others
Protein ID: WP_045356712.1
Location: 4199491..4200411 (921 bp)
Type: Others
Protein ID: WP_223604393.1
Location: 4202389..4202997 (609 bp)
Type: Others
Protein ID: WP_223604396.1
Location: 4198960..4199349 (390 bp)
Type: Others
Protein ID: WP_223604392.1
Location: 4200487..4200789 (303 bp)
Type: Antitoxin
Protein ID: WP_029741460.1
Location: 4200794..4201147 (354 bp)
Type: Toxin
Protein ID: WP_223604394.1
Location: 4201325..4202218 (894 bp)
Type: Others
Protein ID: WP_223604395.1
Location: 4203041..4203991 (951 bp)
Type: Others
Protein ID: WP_223604397.1
Location: 4204088..4205005 (918 bp)
Type: Others
Protein ID: WP_008499475.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KGP20_RS20630 (KGP20_20545)4196447..4198636+2190WP_045356712.1TonB-dependent siderophore receptor-
KGP20_RS20640 (KGP20_20555)4198960..4199349-390WP_223604392.1RidA family protein-
KGP20_RS20645 (KGP20_20560)4199491..4200411+921WP_223604393.1LysR family transcriptional regulator-
KGP20_RS20650 (KGP20_20565)4200487..4200789-303WP_029741460.1XRE family transcriptional regulatorAntitoxin
KGP20_RS20655 (KGP20_20570)4200794..4201147-354WP_223604394.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KGP20_RS20660 (KGP20_20575)4201325..4202218-894WP_223604395.1LysR substrate-binding domain-containing protein-
KGP20_RS20665 (KGP20_20580)4202389..4202997+609WP_223604396.1glutathione S-transferase family protein-
KGP20_RS20670 (KGP20_20585)4203041..4203991-951WP_223604397.1HTH-type transcriptional regulator Cbl-
KGP20_RS20675 (KGP20_20590)4204088..4205005-918WP_008499475.1nitrogen assimilation transcriptional regulator NAC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-106)

Antitoxin

(33-79)


Sequences


Toxin        


Download         Length: 118 a.a.        Molecular weight: 13547.40 Da        Isoelectric Point: 9.0310

>T201777 WP_223604394.1 NZ_CP074177:c4201147-4200794 [Enterobacter asburiae]
VWAINTTDRFDRWFTSLDDTERASVLAALLVLREKGLGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLNTLKERE

Download         Length: 354 bp

>T201777 NZ_CP098757:c5535427-5535011 [Klebsiella oxytoca]
GTGATCAAAACCTATATGCTGGACACCAACATTTGCTCATTTATCATGCGTGAGCAACCGGAAGCTGTCATCAAACGGCT
AGAACAGGCAGTACTGCGTAATCACCGCATCGTGGTTTCGGCCATCACCTATGCCGAGATGCGTTTCGGTGCGATCGGAA
AGAAGGCATCCCCCCGCCACGGCCTGCTTGTCGAAGCTTTCTGCGCCCGCCTCGATGCAATCCTCGCCTGGGACCGCGCC
GCGGTGGACGCAACCACGGAGATTAAGGCCGCACTGACTGCGGCCGGGACGCCAATTGGTCCGAACGACACGGCAATTGC
CGGGCATGCTATCGCCGCCGGCGCCGTACTGGTGACGAACAACGTGCGAGAGTTTGAGCGTGTGCCTGGACTAATTCTGG
AAGACTGGGCTAACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11050.83 Da        Isoelectric Point: 5.7316

>AT201777 WP_029741460.1 NZ_CP074177:c4200789-4200487 [Enterobacter asburiae]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT201777 NZ_CP098757:c5535654-5535424 [Klebsiella oxytoca]
ATGAGAACCGTATCGATATTTAAAAACGGCAATAATCGTGCTATCCGTCTGCCCCGAGACCTGGATTTTGAGGGAGTGAG
CGAACTGGAAATCGTCCGGGAAGGTGACAGCATCATCCTTCGTCCCGTTCGACCAACATGGGGTTCGTTTACTCAGCTCG
AAAAAGCCGATTCAGACTTTATGGCCGAGCGTGGTGACATTGTCAGCGATGAAGGACGATTTGACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1Z3MX79

References