Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1083562..1084208 Replicon chromosome
Accession NZ_CP074177
Organism Enterobacter asburiae strain JBIWA002

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KGP20_RS05540 Protein ID WP_223605289.1
Coordinates 1083562..1083912 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KGP20_RS05545 Protein ID WP_223604894.1
Coordinates 1083909..1084208 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP20_RS05530 (KGP20_05495) 1080776..1082167 - 1392 WP_223604893.1 glycoside-pentoside-hexuronide family transporter -
KGP20_RS05540 (KGP20_05505) 1083562..1083912 + 351 WP_223605289.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP20_RS05545 (KGP20_05510) 1083909..1084208 + 300 WP_223604894.1 XRE family transcriptional regulator Antitoxin
KGP20_RS05550 (KGP20_05515) 1084238..1084675 - 438 WP_223604895.1 acetyltransferase -
KGP20_RS05555 (KGP20_05520) 1084803..1085801 - 999 WP_223604896.1 class I SAM-dependent methyltransferase -
KGP20_RS05560 (KGP20_05525) 1085887..1086825 - 939 WP_223605290.1 helix-turn-helix domain-containing protein -
KGP20_RS05565 (KGP20_05530) 1087015..1087494 - 480 WP_023309865.1 hypothetical protein -
KGP20_RS05570 (KGP20_05535) 1087496..1088257 - 762 WP_223604897.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(42-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13547.63 Da        Isoelectric Point: 8.0096

>T201763 WP_223605289.1 NZ_CP074177:1083562-1083912 [Enterobacter asburiae]
MWTVLFGKVFEQWLLEQEEGLQDKVLADLLNLQNYGPRLPRPYADTVKGSRYNHMKELRIQYAGRPIRAFFAFDPVRQAI
VLCAGDKSNDKAFYEKMIRIADAEFFFHLTSLEATK

Download         Length: 351 bp

>T201763 NZ_CP098749:260484-260717 [Brachyspira pilosicoli]
ATGAGTAAGCTAATTTTGAAGGACGCAAAAACTATAGAAAAATTGTTGTTTTTATTAGGGTTTGTTAAACAGAGGCAGAA
AGGAAGTCATGCCTTTTATAAACATGAGGACGGACGATGCACTGTTATACCTTTTCACTCAAGCAAGGTAATATCAAGAC
CGCTTATGAGAAAAATATTAAATGAAATAAATCTTGATGTAGAAGAATATAATAATCTTATAGAAAAAATTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11147.95 Da        Isoelectric Point: 7.2052

>AT201763 WP_223604894.1 NZ_CP074177:1083909-1084208 [Enterobacter asburiae]
VKTLNEVIASRSPESQQRIKEMADEMILETGLQLLREELRLSQKNVADLMGVSQPAVTQLEQRGNELKIATLKRYIEAIG
GKLHIDIELPTGKRVAFHI

Download         Length: 300 bp

>AT201763 NZ_CP098749:260266-260487 [Brachyspira pilosicoli]
ATGAAGAAAAAGTTTTTTGCATATATAGAATATGATAAAGAAACCAATGTTTATGTGGGATATATTCCTTCAATAGTTGG
GGCACATACACAGGCTGACACTTTGGAAGAGTTGCATATAAAATTAAAAGAGGTTTTGGATTTATGTCTTGAAGAGATGG
ACAGCGAAGAAAAGAAGACTATTCCAGAGTTTGTAAAAGTAGAAGAGATAGAGCTTGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References