Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 112437..112938 Replicon plasmid pJBIWA003_1
Accession NZ_CP074171
Organism Enterobacter sp. JBIWA003

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KGP25_RS25050 Protein ID WP_123061045.1
Coordinates 112663..112938 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KGP25_RS25045 Protein ID WP_103061436.1
Coordinates 112437..112682 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP25_RS25020 (KGP25_24875) 107860..108378 + 519 WP_223540708.1 antirestriction protein -
KGP25_RS25025 (KGP25_24880) 108390..108845 - 456 WP_143345793.1 transglycosylase SLT domain-containing protein -
KGP25_RS25030 (KGP25_24885) 109313..109687 + 375 WP_123061042.1 conjugal transfer relaxosome DNA-binding protein TraM -
KGP25_RS25040 (KGP25_24900) 111950..112195 - 246 WP_123061044.1 hypothetical protein -
KGP25_RS25045 (KGP25_24905) 112437..112682 + 246 WP_103061436.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KGP25_RS25050 (KGP25_24910) 112663..112938 + 276 WP_123061045.1 Txe/YoeB family addiction module toxin Toxin
KGP25_RS25055 (KGP25_24915) 113051..113257 + 207 WP_123061046.1 hypothetical protein -
KGP25_RS25060 (KGP25_24920) 113254..113571 + 318 WP_223540614.1 hypothetical protein -
KGP25_RS25065 (KGP25_24925) 113645..114777 - 1133 Protein_129 IS3 family transposase -
KGP25_RS25070 (KGP25_24930) 114839..115358 + 520 Protein_130 IS3 family transposase -
KGP25_RS25075 (KGP25_24935) 115739..116311 + 573 WP_123061076.1 hypothetical protein -
KGP25_RS25080 (KGP25_24940) 116349..116864 + 516 WP_223540615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid oqxB / oqxA / blaFRI-5 vipA/tssB / vipB/tssC / vasE/tssK / dotU/tssL / hcp/tssD / clpV/tssH / vgrG/tssI / tli1 / tli1 / tle1 / KPHS_23120 / icmF/tssM / tssF / tssG / sciN/tssJ 1..221552 221552


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10891.43 Da        Isoelectric Point: 10.4471

>T201753 WP_123061045.1 NZ_CP074171:112663-112938 [Enterobacter sp. JBIWA003]
MSKWNIKFTRNGADDLSYWRDTDKKKFERIRQLLRSIEADPLTGIGKPERLRHHKDPALYSRRIDQSHRLVYSIKSGEII
IYAARYHYGDK

Download         Length: 276 bp

>T201753 NZ_CP098743:c304203-304108 [Enterococcus faecalis]
ATGTACGACATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9289.43 Da        Isoelectric Point: 4.5069

>AT201753 WP_103061436.1 NZ_CP074171:112437-112682 [Enterobacter sp. JBIWA003]
MHAINFTDARKHFADTMKRVTDDAEPVRVMRRDAPDIVMIDAGEYEALIETVYLFSNPANAAHINESMKQAERGEFVEVE
Y

Download         Length: 246 bp

>AT201753 NZ_CP098743:304008-304073 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References