Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1578543..1579203 Replicon chromosome
Accession NZ_CP074168
Organism Serratia ureilytica strain JBIWA004

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KGP23_RS07430 Protein ID WP_089197226.1
Coordinates 1578543..1578896 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag KGP23_RS07435 Protein ID WP_016927038.1
Coordinates 1578901..1579203 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP23_RS07410 (KGP23_07400) 1574613..1574999 + 387 WP_223524775.1 diacylglycerol kinase -
KGP23_RS07415 (KGP23_07405) 1575102..1576001 + 900 WP_141998516.1 LysR family transcriptional regulator -
KGP23_RS07420 (KGP23_07410) 1575976..1576782 - 807 WP_223524777.1 substrate-binding domain-containing protein -
KGP23_RS07425 (KGP23_07415) 1576809..1578104 - 1296 WP_033643756.1 MFS transporter -
KGP23_RS07430 (KGP23_07420) 1578543..1578896 + 354 WP_089197226.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP23_RS07435 (KGP23_07425) 1578901..1579203 + 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
KGP23_RS07440 (KGP23_07430) 1579618..1580826 + 1209 WP_182074628.1 aldose 1-epimerase family protein -
KGP23_RS07450 (KGP23_07440) 1581432..1582550 + 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
KGP23_RS07455 (KGP23_07445) 1582675..1583589 + 915 WP_033643752.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13403.31 Da        Isoelectric Point: 9.0587

>T201720 WP_089197226.1 NZ_CP074168:1578543-1578896 [Serratia ureilytica]
VWEIKTTDAFDHGFRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T201720 NZ_CP098727:2329076-2329342 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT201720 WP_016927038.1 NZ_CP074168:1578901-1579203 [Serratia ureilytica]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT201720 NZ_CP098727:2328819-2329076 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References