Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1254639..1255366 Replicon chromosome
Accession NZ_CP074149
Organism Enterobacter sp. JBIWA008

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KGP24_RS06115 Protein ID WP_223562699.1
Coordinates 1255055..1255366 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KGP24_RS06110 Protein ID WP_223562698.1
Coordinates 1254639..1255058 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP24_RS06100 (KGP24_06095) 1252469..1253590 - 1122 WP_045401965.1 YbdK family carboxylate-amine ligase -
KGP24_RS06105 (KGP24_06100) 1253696..1254586 + 891 WP_223562697.1 oxidoreductase -
KGP24_RS06110 (KGP24_06105) 1254639..1255058 - 420 WP_223562698.1 helix-turn-helix domain-containing protein Antitoxin
KGP24_RS06115 (KGP24_06110) 1255055..1255366 - 312 WP_223562699.1 type II toxin-antitoxin system HigB family toxin Toxin
KGP24_RS06120 (KGP24_06115) 1255904..1256161 + 258 WP_137467519.1 hypothetical protein -
KGP24_RS06125 (KGP24_06120) 1256331..1256786 - 456 WP_223562700.1 hypothetical protein -
KGP24_RS06130 (KGP24_06125) 1257360..1257572 + 213 WP_022647355.1 RNA chaperone/antiterminator CspA -
KGP24_RS06135 (KGP24_06130) 1257800..1258696 - 897 WP_223562701.1 LysR family transcriptional regulator -
KGP24_RS06140 (KGP24_06135) 1258802..1259581 + 780 WP_223562702.1 acetolactate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12354.28 Da        Isoelectric Point: 10.2553

>T201666 WP_223562699.1 NZ_CP074149:c1255366-1255055 [Enterobacter sp. JBIWA008]
MHVVSRAPFDTATRQFPNQALALGDLYRVLKKEHYPSPDDMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFLADFERGKI
FIKHISTHAEYDKLTELYRRTKE

Download         Length: 312 bp

>T201666 NZ_CP098710:c3038988-3038668 [Yersinia ruckeri]
ATGCACATTTCATCTGTACCGGCCACGGTGCCGGTTGCGTCACGCTTGTCGCCCGTACAGGTCTGGCAGCAACTTTTAAC
GTATCTGCTGGATCACCATTACGGCCTGACGCTTAACGACACGCCATTCCACAACGACGCGGCCATTCAGGAACATATTG
AAGCAGGAATAACACTTTCTGATGCGGTAAATTTCCTGGTGGAACGCTATGAACTGGTTCGCTCTGACCGTAAAGGGTTT
AGCTGGCAGGAACAGACTCCGTTCCTGACCACGACTGATATTCTCCGAGCCAGGCGAGCTACTGGATTGATTAACAAGTA
A

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15496.44 Da        Isoelectric Point: 4.4285

>AT201666 WP_223562698.1 NZ_CP074149:c1255058-1254639 [Enterobacter sp. JBIWA008]
MNYAAAIKAANDLTNELPFLGSSPSRQDYEDALALVEYLVEHEPDSSLVEMLTAKIDKYENESPEFAEFNSRVASIPSGV
ALLRTLIDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFDLPVSAFVGN

Download         Length: 420 bp

>AT201666 NZ_CP098710:c3039348-3039025 [Yersinia ruckeri]
ATGCCATTAACACCACCTCATGAATGGGGTTTACAAAGCGATATCACCCCACGATTTGGCGCAAGATTGGTTCAGGAAGG
TAACCGGCTGCATTACCTGGCTGACAGGGCTGGGTTGACGGGGAGCTTTAGCCCGGAGCAATTACAGAAACTGGATCAGG
CTTTCCCACTGTTTATAGATCAACTGGAAGCAATGCTGCATTCCGGTGAGCTAAACCCACACCAGCAACATCAGGTGACC
ATTCAGCTTGCGAGTTTAACCTGCATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCGATTTATCCAACCCA
GTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References