Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3685505..3686165 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name higB Uniprot ID A0A370T7Q5
Locus tag KGP17_RS17125 Protein ID WP_021805809.1
Coordinates 3685812..3686165 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID U2NFA4
Locus tag KGP17_RS17120 Protein ID WP_021180280.1
Coordinates 3685505..3685807 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS17100 (KGP17_17035) 3680832..3682001 + 1170 WP_223498022.1 flavin-dependent monooxygenase -
KGP17_RS17105 (KGP17_17040) 3682022..3682966 + 945 WP_223498023.1 flavin reductase family protein -
KGP17_RS17110 (KGP17_17045) 3683039..3684241 - 1203 WP_094982866.1 Bcr/CflA family multidrug efflux MFS transporter -
KGP17_RS17115 (KGP17_17050) 3684501..3685361 - 861 WP_223498024.1 aldo/keto reductase family oxidoreductase -
KGP17_RS17120 (KGP17_17055) 3685505..3685807 - 303 WP_021180280.1 XRE family transcriptional regulator Antitoxin
KGP17_RS17125 (KGP17_17060) 3685812..3686165 - 354 WP_021805809.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP17_RS17130 (KGP17_17065) 3686423..3687610 - 1188 WP_021805810.1 sugar transporter -
KGP17_RS17135 (KGP17_17070) 3687784..3688500 - 717 WP_021805811.1 ABC transporter ATP-binding protein -
KGP17_RS17140 (KGP17_17075) 3688497..3689372 - 876 WP_223498025.1 ATP-binding cassette domain-containing protein -
KGP17_RS17145 (KGP17_17080) 3689369..3690655 - 1287 WP_218519156.1 high-affinity branched-chain amino acid ABC transporter permease LivM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13605.59 Da        Isoelectric Point: 10.1319

>T201649 WP_021805809.1 NZ_CP074147:c3686165-3685812 [Serratia sp. JSRIV001]
VWKIKTTDTFDEWFSRLDDTDRASVLASLMVLREKGPQLPRPYADTVKGSRYSNMKELRVQSRGIPIRAFFAFDPRRRGI
LLCAGNKAGNEKRFYEVMIPIADREFTQFLNTAENKE

Download         Length: 354 bp

>T201649 NZ_CP098703:c3129082-3128792 [Yersinia ruckeri]
ATGACCTTTAATATCGACTTTGACGAACGGGCATTAAAAGAATGGCACAAACTAGATAAAACTATCCGAGAGCAATTTAA
AAAGAAACTAAGAAAATTACAGGAAAATCCCTATATTGAATCAGCACGTTTGCACGGTGATCTGGCTGGTTGTTTCAAAA
TAAAATTACGCGCATCTGGCTTTCGGTTGATTTACCAAGTTATCGATGAGGAGATTGTGATTTGGATCGTTGCTGTTGGT
AAACGGGAAGATGAAAAAGCTTATGATATTGCCAAGAAGCGAATCCAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11022.78 Da        Isoelectric Point: 6.4749

>AT201649 WP_021180280.1 NZ_CP074147:c3685807-3685505 [Serratia sp. JSRIV001]
MGRTLEQILAEEKPEVVASAERIAADTLLNIHLAELRERVQKTQVEMAQALGIKQPTVAGMEKPGRDLKLSSLKRYIEAA
GGKLRLDIELPDGSHYGFVI

Download         Length: 303 bp

>AT201649 NZ_CP098703:c3129326-3129072 [Yersinia ruckeri]
ATGAGTACTATCCAAATTCGTGTGGATGATGAACTGAAGAAAAGTGCATATCAGGCGTTTGAAAAACTGAATCTTTCGCC
TTCTGATGCACTACGCCTGTTCCTACGTTATGTTGCAGAGAACGAAAAGCTGCCTTTTTCAGAAGTATCCGTCATGGTCA
GTAATCAAGATGAGGATGCTGATATTTTGGCTGTTGTCCGTGAACGTTTGAAAAATCCTGCAAAGCGTATCAGAGTAAAT
ATTGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A370T7Q5

Antitoxin

Source ID Structure
AlphaFold DB U2NFA4

References