Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 720093..720749 Replicon chromosome
Accession NZ_CP074147
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name higB Uniprot ID A0A7Y8XPF0
Locus tag KGP17_RS03195 Protein ID WP_039995466.1
Coordinates 720426..720749 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4P8TYG0
Locus tag KGP17_RS03190 Protein ID WP_071682469.1
Coordinates 720093..720383 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS03165 (KGP17_03155) 715766..716494 - 729 WP_223498855.1 RES family NAD+ phosphorylase -
KGP17_RS03170 (KGP17_03160) 716475..717236 - 762 WP_223498856.1 hypothetical protein -
KGP17_RS03175 (KGP17_03165) 717362..718183 - 822 WP_021807988.1 helix-turn-helix transcriptional regulator -
KGP17_RS03180 (KGP17_03170) 718327..718839 + 513 WP_021807989.1 helix-turn-helix domain-containing protein -
KGP17_RS03185 (KGP17_03175) 719120..720040 + 921 WP_021179171.1 L,D-transpeptidase family protein -
KGP17_RS03190 (KGP17_03180) 720093..720383 - 291 WP_071682469.1 NadS family protein Antitoxin
KGP17_RS03195 (KGP17_03185) 720426..720749 - 324 WP_039995466.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP17_RS03200 (KGP17_03190) 720967..721683 - 717 WP_021807990.1 GntR family transcriptional regulator -
KGP17_RS03205 (KGP17_03195) 721918..723843 + 1926 WP_179253644.1 PTS 2-O-a-mannosyl-D-glycerate transporter subunit IIABC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-80)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12404.25 Da        Isoelectric Point: 9.2975

>T201637 WP_039995466.1 NZ_CP074147:c720749-720426 [Serratia sp. JSRIV001]
MEYFEFIETPVFSRQRETLLDDDSFRELQTHLLKYHSDGDTISKTGGCKKIRWNRPGMGKQGGVRVIYYVITRSGKLYLL
IVYPKNAKDDLTESEKAILKALTDKLN

Download         Length: 324 bp

>T201637 NZ_CP098701:1897216-1897674 [Yersinia ruckeri]
GTGATGCTCTACCGGATAGTTCACAACCGTTACCTGGCAACGGCCTGGACCGGATATGGCGCAGAAACCTATGGTGGCCG
CTGGAATCATAAAGGCCATGCGGCGATTTATCTGGCCAGTAGCGTTTCTCTGGCGATGCTCGAAACACTGGTGCATGTAG
AAGATAGCGCGACGCTGAACGATTTTAATCTATTTCAGATAACCATTCCCGATAATGCAATTATGGTACTGCAACAGCAA
GATTGGCCACGTGGATGGCGAGATGACCCCACCCCCGTGGCCACCATGGACATCGGCACCGAATGGATTGGTTCAGTATC
ATCTGTCGGTCTGCTGGTACCATCCACGTTAGTCCCTTTGGAAAGAAATATGCTGGTGAATCCTAAACACCGCGATTTCG
CCTCGTGCCTGAAAAGCATCAATCCACTGACGTTCAGTTTTGATCCTTGTCTAAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10900.57 Da        Isoelectric Point: 6.4836

>AT201637 WP_071682469.1 NZ_CP074147:c720383-720093 [Serratia sp. JSRIV001]
VDKELFNDLVESMEQMVAIEKGEMQPARVHRHHIPNVKSLREASGMKQEEFAQAVGVSPSLVQSWEQNRRIPSGSSLKIL
LMIERHPTIVNDLLTI

Download         Length: 291 bp

>AT201637 NZ_CP098701:1896756-1897202 [Yersinia ruckeri]
ATGAGAACTTATCACCCAAGCCCGATGGCCAAAGTCAGCGCACTATGGCGTGAGATTGGTCTACCCGCCAGTCGTGGCAC
CGCTTTGGTGGACAGCATAAAACTGGGATTTACTGTGGATGTGATCGACACTATACATTTATGGGCTGATATGCCTAAAT
CTGAAATATTACGCGCTACGGGCATTCCGAGCCGCAGTCTGACGCGCCGTCGTACCCATGATGGGCGTTTTACCCCGGAA
GAAAGCGAACGTATTGCACGGTTTGTCCGGGTTATGGATGCGGCGGTAGATTTGTTCGGTGGTGACCGCACCAAAGCAAC
CGCATGGATGTCGATGCCGGTCAAAGGGCTGGGTAATCGAACGCCCGATTCACTGCTGGAAACCGAAACCGGTGCGTTGG
AAATCTGCGACCTGATTGGTCGTCTCGAACATGGGGTCTTTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8XPF0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8TYG0

References