Detailed information of TA system TA201634

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 166041..166687
• Replicon: chromosome
• Accession: NZ_CP074147
• Organism: Serratia sp. JSRIV001

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KGP17_RS00685
• Protein ID: WP_021807728.1
• Coordinates: 166041..166391 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A370SDA2
• Locus tag: KGP17_RS00690
• Protein ID: WP_021807729.1
• Coordinates: 166388..166687 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP17_RS00665 (KGP17_00665)	161900..162919	+	1020	WP_037376574.1	dipeptide ABC transporter permease DppB	-
KGP17_RS00670 (KGP17_00670)	162931..163833	+	903	WP_037376575.1	dipeptide ABC transporter permease DppC	-
KGP17_RS00675 (KGP17_00675)	163848..164828	+	981	WP_021807726.1	dipeptide ABC transporter ATP-binding protein	-
KGP17_RS00680 (KGP17_00680)	164825..165814	+	990	WP_021807727.1	peptide ABC transporter ATP-binding protein	-
KGP17_RS00685 (KGP17_00685)	166041..166391	+	351	WP_021807728.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP17_RS00690 (KGP17_00690)	166388..166687	+	300	WP_021807729.1	helix-turn-helix transcriptional regulator	Antitoxin
KGP17_RS00700 (KGP17_00700)	168298..169953	-	1656	WP_021807730.1	cellulose biosynthesis protein BcsG	-
KGP17_RS00705 (KGP17_00705)	169956..170153	-	198	WP_021807731.1	cellulose biosynthesis protein BcsF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13591.49 Da
• Isoelectric Point: 5.2279

>T201634 WP_021807728.1 NZ_CP074147:166041-166391 [Serratia sp. JSRIV001]
MWTVIFTSTFDSWLQEQEEGMQEKVLADLMNLETYGPQLPRPYADTVKGSRYKNMKELRVQYSGRPIRAFFVFDPKRQAI
VLCAGDKSNDKRFYETMIRIADDEFTAYLATQEVSK

Nucleotide

• Length: 351 bp

>T201634 NZ_CP098701:549293-549613 [Yersinia ruckeri]
ATGCAAACCACAACTGTACCGGCCACGTTGCCGGTTTCATCACGCCTGTCTCCCGTCCAGGTGTGGCAACAACTGTTAAC
GTATCTACTGGAACACCATTACGGCTTGACGCTTAACGATACGCCATTTCATGATGACGCATCCATAGAGGAACATATCG
AAGCGGGAATAACGCTTGCTGATGCAGTGAATTTCCTGGTTGAACGCTATGAGCTGGTGCGCACTGACCGCAAAGGATTC
ACTTGGCAGGAGCAAACCCCATTTCTGACCGCTACAGATATTCTCAGAGCAAAGCGGGCTACCGGATTAATGAATACGTA
A

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10894.65 Da
• Isoelectric Point: 5.8719

>AT201634 WP_021807729.1 NZ_CP074147:166388-166687 [Serratia sp. JSRIV001]
MKTLRDAVAARSLESQARIKEMADEMMLETGLQLMRDELQLSQKSLAEAMGVSQSAVAQIEQRGNDVKLATLKRYIEAMG
GKLSLTVEMPEGGGRVFHI

Nucleotide

• Length: 300 bp

>AT201634 NZ_CP098701:548891-549226 [Yersinia ruckeri]
ATGAATAAAGACGCGACCCAAATCTGGGGTCTTAATCGAGATATCACACCATGCTTCGGAGCCCGACTGGTGCAGGAAGG
TAACAGTCTGCATTTTCTGGCGGACCGGGCAGGATTCAATGGTTCGTTCAGTAAGATGCAGGCCCGAGATCTGGATGAAG
CCTTTCCGCATTTTGTCGCGCATATGGAATTGATGTTGCTCTCCGGTGAGCTCAATCCCCGGTACTCGCACTGTGTCACG
TTGTACCGTAACGGGCTGACTTGTGAAGCCGATACGCTGGGCAGTTATGGGTATGTATATATCGCAATTTATCCCTCAAA
TCTGGTTACAGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A370SDA2