201630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 6042245..6042897 Replicon chromosome
Accession NZ_CP074143
Organism Serratia sp. JSRIV002

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KGP26_RS28345 Protein ID WP_223664858.1
Coordinates 6042556..6042897 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KGP26_RS28340 Protein ID WP_021181420.1
Coordinates 6042245..6042559 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP26_RS28325 (KGP26_28240) 6037999..6039828 + 1830 WP_094982457.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
KGP26_RS28330 (KGP26_28245) 6039951..6041066 + 1116 WP_223500570.1 hypothetical protein -
KGP26_RS28335 (KGP26_28250) 6041068..6042147 + 1080 WP_223664857.1 GNAT family N-acetyltransferase -
KGP26_RS28340 (KGP26_28255) 6042245..6042559 - 315 WP_021181420.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
KGP26_RS28345 (KGP26_28260) 6042556..6042897 - 342 WP_223664858.1 toxin Toxin
KGP26_RS28350 (KGP26_28265) 6043265..6044305 + 1041 WP_021181417.1 phosphate ABC transporter substrate-binding protein PstS -
KGP26_RS28355 (KGP26_28270) 6044396..6045352 + 957 WP_021181416.1 phosphate ABC transporter permease PstC -
KGP26_RS28360 (KGP26_28275) 6045354..6046244 + 891 WP_059199278.1 phosphate ABC transporter permease PstA -
KGP26_RS28365 (KGP26_28280) 6046292..6047068 + 777 WP_021181414.1 phosphate ABC transporter ATP-binding protein PstB -
KGP26_RS28370 (KGP26_28285) 6047081..6047812 + 732 WP_024484696.1 phosphate signaling complex protein PhoU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin MqsA/HigA-2

(29-99)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13474.60 Da        Isoelectric Point: 9.7468

>T201630 WP_223664858.1 NZ_CP074143:c6042897-6042556 [Serratia sp. JSRIV002]
MDAIFVELSIFEAKRADYLSDDEFKTFQQMLLNNPFCGDVIQHTGGLRKVRFADHRRGKGKRGGLRVIYYWWLEKSHFLL
FVIYDKDKKDDLSRNEREMLRRMLEILKQGGTL

Download         Length: 342 bp

>T201630 NZ_CP098697:2812884-2813213 [Yersinia ruckeri]
ATGCAAACCTTATCATCACACCCGACACGGGCGTCTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGCTGCTGCTGAC
TCATTTGTTGTCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCATTAATGAAACCACCATCCGGGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATATGGGCTTGTCCGTATCGACCGGAAGGGATTT
TCGTGGCAAGAACAGACCCCATATATTTCCGTAGTTGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACCAA
CGTGAAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11870.69 Da        Isoelectric Point: 7.2018

>AT201630 WP_021181420.1 NZ_CP074143:c6042559-6042245 [Serratia sp. JSRIV002]
MSELSLFEELSQGMKDWSDYNEGKITLKTHAVSLKKNISMSPDELKAIREKLRLSQAVFADYLHTGVTTYQNWEQGRAKP
NKQALLLIRMVEKDPMTLDTLAAL

Download         Length: 315 bp

>AT201630 NZ_CP098697:2812480-2812845 [Yersinia ruckeri]
ATGAACAATCACTCAGAATCCGTTACCAAGCCGGAGAATCCCGCCTGCCAGCAGTGGGGACTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGTCTGGTGCTGGAAGGCAACCGCTTGCATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GCGACGATGACGCGCTGCACCTAGATCATGCCTTTCCGTTGATACTCAAGCAACTGGAGCTGATGCTCACCAGCGGAGAA
CTCTCTCCCCGGCATCAGCACTGCGTCACGCTATATCACAACGGACTCACTTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATTGCTATTTATCCTGACCAGACTGAGCCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References