201605

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 261977..262623 Replicon chromosome
Accession NZ_CP074143
Organism Serratia sp. JSRIV002

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KGP26_RS01140 Protein ID WP_021807728.1
Coordinates 261977..262327 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A370SDA2
Locus tag KGP26_RS01145 Protein ID WP_021807729.1
Coordinates 262324..262623 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP26_RS01120 (KGP26_01115) 257836..258855 + 1020 WP_037376574.1 dipeptide ABC transporter permease DppB -
KGP26_RS01125 (KGP26_01120) 258867..259769 + 903 WP_037376575.1 dipeptide ABC transporter permease DppC -
KGP26_RS01130 (KGP26_01125) 259784..260764 + 981 WP_021807726.1 dipeptide ABC transporter ATP-binding protein -
KGP26_RS01135 (KGP26_01130) 260761..261750 + 990 WP_021181580.1 peptide ABC transporter ATP-binding protein -
KGP26_RS01140 (KGP26_01135) 261977..262327 + 351 WP_021807728.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP26_RS01145 (KGP26_01140) 262324..262623 + 300 WP_021807729.1 helix-turn-helix transcriptional regulator Antitoxin
KGP26_RS01150 (KGP26_01145) 262785..264440 - 1656 WP_094982245.1 cellulose biosynthesis protein BcsG -
KGP26_RS01155 (KGP26_01150) 264443..264640 - 198 WP_021807731.1 cellulose biosynthesis protein BcsF -
KGP26_RS01160 (KGP26_01155) 264637..266199 - 1563 WP_223664917.1 cellulose biosynthesis protein BcsE -
KGP26_RS01165 (KGP26_01160) 266394..266588 + 195 WP_021807733.1 cellulose biosynthesis protein BcsR -
KGP26_RS01170 (KGP26_01165) 266592..267329 + 738 WP_059199122.1 cellulose biosynthesis protein BcsQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13591.49 Da        Isoelectric Point: 5.2279

>T201605 WP_021807728.1 NZ_CP074143:261977-262327 [Serratia sp. JSRIV002]
MWTVIFTSTFDSWLQEQEEGMQEKVLADLMNLETYGPQLPRPYADTVKGSRYKNMKELRVQYSGRPIRAFFVFDPKRQAI
VLCAGDKSNDKRFYETMIRIADDEFTAYLATQEVSK

Download         Length: 351 bp

>T201605 NZ_CP098691:c2122119-2122026 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10894.65 Da        Isoelectric Point: 5.8719

>AT201605 WP_021807729.1 NZ_CP074143:262324-262623 [Serratia sp. JSRIV002]
MKTLRDAVAARSLESQARIKEMADEMMLETGLQLMRDELQLSQKSLAEAMGVSQSAVAQIEQRGNDVKLATLKRYIEAMG
GKLSLTVEMPEGGGRVFHI

Download         Length: 300 bp

>AT201605 NZ_CP098691:2122022-2122168 [Yersinia ruckeri]
AGATAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A370SDA2

References