Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 867552..868208 Replicon chromosome
Accession NZ_CP074140
Organism Serratia sp. JSRIV004

Toxin (Protein)


Gene name higB Uniprot ID A0A7Y8XPF0
Locus tag KGP21_RS04060 Protein ID WP_039995466.1
Coordinates 867885..868208 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4P8TYG0
Locus tag KGP21_RS04055 Protein ID WP_071682469.1
Coordinates 867552..867842 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP21_RS04030 (KGP21_04010) 863225..863953 - 729 WP_223537268.1 RES family NAD+ phosphorylase -
KGP21_RS04035 (KGP21_04015) 863934..864695 - 762 WP_051363780.1 hypothetical protein -
KGP21_RS04040 (KGP21_04020) 864821..865642 - 822 WP_021807988.1 helix-turn-helix transcriptional regulator -
KGP21_RS04045 (KGP21_04025) 865786..866298 + 513 WP_209530243.1 helix-turn-helix domain-containing protein -
KGP21_RS04050 (KGP21_04030) 866579..867499 + 921 WP_021179171.1 L,D-transpeptidase family protein -
KGP21_RS04055 (KGP21_04035) 867552..867842 - 291 WP_071682469.1 NadS family protein Antitoxin
KGP21_RS04060 (KGP21_04040) 867885..868208 - 324 WP_039995466.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP21_RS04065 (KGP21_04045) 868426..869142 - 717 WP_021807990.1 GntR family transcriptional regulator -
KGP21_RS04070 (KGP21_04050) 869376..871301 + 1926 WP_179253644.1 PTS 2-O-a-mannosyl-D-glycerate transporter subunit IIABC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-80)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12404.25 Da        Isoelectric Point: 9.2975

>T201581 WP_039995466.1 NZ_CP074140:c868208-867885 [Serratia sp. JSRIV004]
MEYFEFIETPVFSRQRETLLDDDSFRELQTHLLKYHSDGDTISKTGGCKKIRWNRPGMGKQGGVRVIYYVITRSGKLYLL
IVYPKNAKDDLTESEKAILKALTDKLN

Download         Length: 324 bp

>T201581 NZ_CP098604:c1976992-1976858 [Xanthomonas hortorum pv. pelargonii]
ATGAAGCGTGCAATTATGCTGCTGGTGCTGTCGGTGTTTTCGGTCGGTATGTTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAAGTGGAAGACGCTGCGCGCAAGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10900.57 Da        Isoelectric Point: 6.4836

>AT201581 WP_071682469.1 NZ_CP074140:c867842-867552 [Serratia sp. JSRIV004]
VDKELFNDLVESMEQMVAIEKGEMQPARVHRHHIPNVKSLREASGMKQEEFAQAVGVSPSLVQSWEQNRRIPSGSSLKIL
LMIERHPTIVNDLLTI

Download         Length: 291 bp

>AT201581 NZ_CP098604:c1977223-1977071 [Xanthomonas hortorum pv. pelargonii]
ATGAAGCGACTGCTGACACTGATGGTGCTAGGCCTGTTTTCGGCTGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
CGGCAAGGACATGCAGGGCGCAGGTGAGAAGGTCGAAAAGAAGGCCGATAATTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8XPF0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8TYG0

References