Detailed information of TA system TA201572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 5717794..5718446
• Replicon: chromosome
• Accession: NZ_CP074137
• Organism: Serratia sp. JSRIV006

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U2LU32
• Locus tag: KGP16_RS26430
• Protein ID: WP_021181419.1
• Coordinates: 5718105..5718446 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KGP16_RS26425
• Protein ID: WP_021181420.1
• Coordinates: 5717794..5718108 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP16_RS26410 (KGP16_26335)	5713548..5715377	+	1830	WP_115160432.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
KGP16_RS26415 (KGP16_26340)	5715500..5716615	+	1116	WP_223500570.1	hypothetical protein	-
KGP16_RS26420 (KGP16_26345)	5716617..5717696	+	1080	WP_223500571.1	GNAT family N-acetyltransferase	-
KGP16_RS26425 (KGP16_26350)	5717794..5718108	-	315	WP_021181420.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
KGP16_RS26430 (KGP16_26355)	5718105..5718446	-	342	WP_021181419.1	hypothetical protein	Toxin
KGP16_RS26435 (KGP16_26360)	5718814..5719854	+	1041	WP_021181417.1	phosphate ABC transporter substrate-binding protein PstS	-
KGP16_RS26440 (KGP16_26365)	5719945..5720901	+	957	WP_024527373.1	phosphate ABC transporter permease PstC	-
KGP16_RS26445 (KGP16_26370)	5720903..5721793	+	891	WP_059199278.1	phosphate ABC transporter permease PstA	-
KGP16_RS26450 (KGP16_26375)	5721841..5722617	+	777	WP_021181414.1	phosphate ABC transporter ATP-binding protein PstB	-
KGP16_RS26455 (KGP16_26380)	5722630..5723361	+	732	WP_024484696.1	phosphate signaling complex protein PhoU	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin MqsA/HigA-2 (29-99)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13473.66 Da
• Isoelectric Point: 9.7468

>T201572 WP_021181419.1 NZ_CP074137:c5718446-5718105 [Serratia sp. JSRIV006]
MDAIFVELSIFEAKRADYLSDDEFKTFQQMLLINPFCGDVIQHTGGLRKVRFADHRRGKGKRGGLRVIYYWWLEKSHFLL
FVIYDKDKKDDLSRNEREMLRRMLEILKQGGTL

Nucleotide

• Length: 342 bp

>T201572 NZ_CP098546:c948833-948414 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11870.69 Da
• Isoelectric Point: 7.2018

>AT201572 WP_021181420.1 NZ_CP074137:c5718108-5717794 [Serratia sp. JSRIV006]
MSELSLFEELSQGMKDWSDYNEGKITLKTHAVSLKKNISMSPDELKAIREKLRLSQAVFADYLHTGVTTYQNWEQGRAKP
NKQALLLIRMVEKDPMTLDTLAAL

Nucleotide

• Length: 315 bp

>AT201572 NZ_CP098546:c949069-948833 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Structures

Toxin

• AlphaFold DB: U2LU32