Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 740496..741152 Replicon chromosome
Accession NZ_CP074137
Organism Serratia sp. JSRIV006

Toxin (Protein)


Gene name higB Uniprot ID A0A7Y8XPF0
Locus tag KGP16_RS03390 Protein ID WP_039995466.1
Coordinates 740829..741152 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4P8TYG0
Locus tag KGP16_RS03385 Protein ID WP_071682469.1
Coordinates 740496..740786 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP16_RS03360 (KGP16_03345) 736169..736897 - 729 WP_021807986.1 RES family NAD+ phosphorylase -
KGP16_RS03365 (KGP16_03350) 736878..737639 - 762 WP_051363780.1 hypothetical protein -
KGP16_RS03370 (KGP16_03355) 737765..738586 - 822 WP_021807988.1 helix-turn-helix transcriptional regulator -
KGP16_RS03375 (KGP16_03360) 738730..739242 + 513 WP_209530243.1 helix-turn-helix domain-containing protein -
KGP16_RS03380 (KGP16_03365) 739523..740443 + 921 WP_021179171.1 L,D-transpeptidase family protein -
KGP16_RS03385 (KGP16_03370) 740496..740786 - 291 WP_071682469.1 NadS family protein Antitoxin
KGP16_RS03390 (KGP16_03375) 740829..741152 - 324 WP_039995466.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP16_RS03395 (KGP16_03380) 741370..742086 - 717 WP_021807990.1 GntR family transcriptional regulator -
KGP16_RS03400 (KGP16_03385) 742321..744246 + 1926 WP_179253644.1 PTS 2-O-a-mannosyl-D-glycerate transporter subunit IIABC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-80)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12404.25 Da        Isoelectric Point: 9.2975

>T201552 WP_039995466.1 NZ_CP074137:c741152-740829 [Serratia sp. JSRIV006]
MEYFEFIETPVFSRQRETLLDDDSFRELQTHLLKYHSDGDTISKTGGCKKIRWNRPGMGKQGGVRVIYYVITRSGKLYLL
IVYPKNAKDDLTESEKAILKALTDKLN

Download         Length: 324 bp

>T201552 NZ_CP098521:458046-458435 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10900.57 Da        Isoelectric Point: 6.4836

>AT201552 WP_071682469.1 NZ_CP074137:c740786-740496 [Serratia sp. JSRIV006]
VDKELFNDLVESMEQMVAIEKGEMQPARVHRHHIPNVKSLREASGMKQEEFAQAVGVSPSLVQSWEQNRRIPSGSSLKIL
LMIERHPTIVNDLLTI

Download         Length: 291 bp

>AT201552 NZ_CP098521:457782-458039 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8XPF0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8TYG0

References