Detailed information of TA system TA201547

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 180288..180934
• Replicon: chromosome
• Accession: NZ_CP074137
• Organism: Serratia sp. JSRIV006

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KGP16_RS00805
• Protein ID: WP_021807728.1
• Coordinates: 180288..180638 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A370SDA2
• Locus tag: KGP16_RS00810
• Protein ID: WP_021807729.1
• Coordinates: 180635..180934 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP16_RS00785 (KGP16_00780)	176147..177166	+	1020	WP_037376574.1	dipeptide ABC transporter permease DppB	-
KGP16_RS00790 (KGP16_00785)	177178..178080	+	903	WP_218520002.1	dipeptide ABC transporter permease DppC	-
KGP16_RS00795 (KGP16_00790)	178095..179075	+	981	WP_021807726.1	dipeptide ABC transporter ATP-binding protein	-
KGP16_RS00800 (KGP16_00795)	179072..180061	+	990	WP_021181580.1	peptide ABC transporter ATP-binding protein	-
KGP16_RS00805 (KGP16_00800)	180288..180638	+	351	WP_021807728.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP16_RS00810 (KGP16_00805)	180635..180934	+	300	WP_021807729.1	helix-turn-helix transcriptional regulator	Antitoxin
KGP16_RS00815 (KGP16_00810)	181096..182751	-	1656	WP_223500646.1	cellulose biosynthesis protein BcsG	-
KGP16_RS00820 (KGP16_00815)	182754..182951	-	198	WP_223500647.1	cellulose biosynthesis protein BcsF	-
KGP16_RS00825 (KGP16_00820)	182948..184510	-	1563	WP_223500648.1	cellulose biosynthesis protein BcsE	-
KGP16_RS00830 (KGP16_00825)	184705..184899	+	195	WP_223500649.1	cellulose biosynthesis protein BcsR	-
KGP16_RS00835 (KGP16_00830)	184903..185640	+	738	WP_223500650.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13591.49 Da
• Isoelectric Point: 5.2279

>T201547 WP_021807728.1 NZ_CP074137:180288-180638 [Serratia sp. JSRIV006]
MWTVIFTSTFDSWLQEQEEGMQEKVLADLMNLETYGPQLPRPYADTVKGSRYKNMKELRVQYSGRPIRAFFVFDPKRQAI
VLCAGDKSNDKRFYETMIRIADDEFTAYLATQEVSK

Nucleotide

• Length: 351 bp

>T201547 NZ_CP098508:52113-52454 [Listeria monocytogenes]
ATGGTAAAGCAAGGCGATATTATCAAGATCAATCTAAATCCAAAACAGGGACACGAGCAGCAAGGCTATCGGCCCTATAT
TTGCCTCAGTCATCATCTGGTAAGTGATTATGCAAATATCGCGATCTTTGCCCCAATCAGTAATACACCGCGCACCTATC
CGTTATATGTGCCTTTGACAGGGACAACCACAACCGGAAAAGTATTGCTGGATCAACTAGTTACGATCGATTACAACGCT
CGTAAGCATCAATACGTGGAAACTGTTTCGGATCCATTGCTCACAAAGCTATTAGATACAGTAAAAGTTATTTTTCAAAA
GAACGAGAGATCAACCAACTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10894.65 Da
• Isoelectric Point: 5.8719

>AT201547 WP_021807729.1 NZ_CP074137:180635-180934 [Serratia sp. JSRIV006]
MKTLRDAVAARSLESQARIKEMADEMMLETGLQLMRDELQLSQKSLAEAMGVSQSAVAQIEQRGNDVKLATLKRYIEAMG
GKLSLTVEMPEGGGRVFHI

Nucleotide

• Length: 300 bp

>AT201547 NZ_CP098508:51877-52119 [Listeria monocytogenes]
ATGACCACCGTTAGCGTTAAAAAGTGGGGAAATAGCAAAGCTGTTCGTCTCCCCAATAATCTATTAAATGCCTTAGACAT
CAAAGAGAACGATGATTTGAAAGTGGAAGTGATCAATAATCAGATGATCCTTACCAAAACAGCTATCGATCTCCGAATCG
AGGATCTGTTTGCCAATTACCAGGGCGAACCCTTCCAAACTGAGCTGCAAACATTCGAACCAATCGGAGATGAAAAATGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A370SDA2