Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 966040..966548 Replicon chromosome
Accession NZ_CP074133
Organism Nocardiopsis changdeensis strain Mg02

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KGD84_RS04585 Protein ID WP_220564861.1
Coordinates 966040..966300 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KGD84_RS04590 Protein ID WP_220564862.1
Coordinates 966297..966548 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGD84_RS04560 (KGD84_04545) 961148..962047 + 900 WP_220565528.1 transketolase -
KGD84_RS04565 (KGD84_04550) 962259..964037 + 1779 WP_220564857.1 ABC-F family ATP-binding cassette domain-containing protein -
KGD84_RS04570 (KGD84_04555) 964054..964938 - 885 WP_220564858.1 hypothetical protein -
KGD84_RS04575 (KGD84_04560) 964986..965654 - 669 WP_220564859.1 helix-turn-helix domain-containing protein -
KGD84_RS04580 (KGD84_04565) 965808..966035 + 228 WP_220564860.1 hypothetical protein -
KGD84_RS04585 (KGD84_04570) 966040..966300 - 261 WP_220564861.1 Txe/YoeB family addiction module toxin Toxin
KGD84_RS04590 (KGD84_04575) 966297..966548 - 252 WP_220564862.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KGD84_RS04595 (KGD84_04580) 966689..967633 - 945 WP_220565529.1 GDSL-type esterase/lipase family protein -
KGD84_RS04600 (KGD84_04585) 967781..968284 - 504 WP_220564863.1 MarR family transcriptional regulator -
KGD84_RS04605 (KGD84_04590) 968363..969013 - 651 WP_255647046.1 TetR/AcrR family transcriptional regulator -
KGD84_RS04610 (KGD84_04595) 969028..969975 - 948 WP_220564864.1 acyl-CoA desaturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10343.75 Da        Isoelectric Point: 10.0233

>T201545 WP_220564861.1 NZ_CP074133:c966300-966040 [Nocardiopsis changdeensis]
VRLVWSQSAWEDYVWWQGQDRRILKRINALVKDIERNGNEGMGKPEPLRHGFQGYWSRRITDEHRLVYKLAGDEIRIAAC
RYHYGK

Download         Length: 261 bp

>T201545 NZ_CP098505:1207476-1207658 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9392.52 Da        Isoelectric Point: 4.2403

>AT201545 WP_220564862.1 NZ_CP074133:c966548-966297 [Nocardiopsis changdeensis]
MKTMSYTESRANYAATLDAVVNDREEVVITRAGHEPVVMMALSEYETLKETAYLLRSPENARRLVSAIEELESDQGIERE
LAE

Download         Length: 252 bp

>AT201545 NZ_CP098505:1207760-1208161 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References