Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 64830..65094 | Replicon | plasmid pEC16-3 |
| Accession | NZ_CP074123 | ||
| Organism | Escherichia coli strain EC16 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | KGQ53_RS24775 | Protein ID | WP_001387489.1 |
| Coordinates | 64942..65094 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 64830..64892 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KGQ53_RS24760 (60069) | 60069..62360 | - | 2292 | WP_212639657.1 | F-type conjugative transfer protein TrbC | - |
| KGQ53_RS24765 (62353) | 62353..63423 | - | 1071 | WP_039005625.1 | IncI1-type conjugal transfer protein TrbB | - |
| KGQ53_RS24770 (63442) | 63442..64650 | - | 1209 | WP_212639658.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (64830) | 64830..64892 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (64830) | 64830..64892 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (64830) | 64830..64892 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (64830) | 64830..64892 | - | 63 | NuclAT_0 | - | Antitoxin |
| KGQ53_RS24775 (64942) | 64942..65094 | + | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| KGQ53_RS24780 (65166) | 65166..65417 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| KGQ53_RS26190 (65916) | 65916..66011 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| KGQ53_RS24785 (66076) | 66076..66252 | - | 177 | WP_001054898.1 | hypothetical protein | - |
| KGQ53_RS24790 (66644) | 66644..66853 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| KGQ53_RS24795 (66925) | 66925..67575 | - | 651 | WP_001178506.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| KGQ53_RS24800 (67649) | 67649..69817 | - | 2169 | WP_000698357.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | afaC-I | 1..110400 | 110400 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T201535 WP_001387489.1 NZ_CP074123:64942-65094 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T201535 NZ_CP098500:27221-27589 [Serratia symbiotica]
ATGCAGACCTTACCTGTCACCCCGAAACGGGCGGCTTACGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCGCTTAACGATACCGAGTTCAGTGATGATGCTGTGATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGTTGAATTTCACGGTGGAGAAGTTTGACCTGGTTCGCACCGATCGCAGGGGATTC
TCCTGCGAGGAACAATCCCCCTTTATTACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACTGGCCTGATGGTCCGTAT
GGGTTACCAGAGCATCACCTCAGTTATCCGGGGCGAAAAGCAGACATGA
ATGCAGACCTTACCTGTCACCCCGAAACGGGCGGCTTACGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCGCTTAACGATACCGAGTTCAGTGATGATGCTGTGATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGTTGAATTTCACGGTGGAGAAGTTTGACCTGGTTCGCACCGATCGCAGGGGATTC
TCCTGCGAGGAACAATCCCCCTTTATTACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACTGGCCTGATGGTCCGTAT
GGGTTACCAGAGCATCACCTCAGTTATCCGGGGCGAAAAGCAGACATGA
Antitoxin
Download Length: 63 bp
>AT201535 NZ_CP074123:c64892-64830 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
