Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3773762..3774455 Replicon chromosome
Accession NZ_CP074120
Organism Escherichia coli strain EC16

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KGQ53_RS18060 Protein ID WP_000415584.1
Coordinates 3773762..3774058 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KGQ53_RS18065 Protein ID WP_000650107.1
Coordinates 3774060..3774455 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGQ53_RS18025 (3768850) 3768850..3769164 - 315 WP_000958598.1 putative quinol monooxygenase -
KGQ53_RS18030 (3769195) 3769195..3769776 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KGQ53_RS18035 (3770095) 3770095..3770427 + 333 WP_000917685.1 DUF2645 family protein -
KGQ53_RS18040 (3770473) 3770473..3771822 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KGQ53_RS18045 (3771819) 3771819..3772478 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KGQ53_RS18050 (3772630) 3772630..3773022 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KGQ53_RS18055 (3773075) 3773075..3773557 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KGQ53_RS18060 (3773762) 3773762..3774058 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KGQ53_RS18065 (3774060) 3774060..3774455 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KGQ53_RS18070 (3774588) 3774588..3776195 + 1608 WP_087523553.1 ABC transporter substrate-binding protein -
KGQ53_RS18075 (3776333) 3776333..3778591 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T201521 WP_000415584.1 NZ_CP074120:3773762-3774058 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T201521 NZ_CP098480:3139463-3139882 [Acinetobacter sp. C32I]
ATGCAGACACAATATTTATTGGATACCAATATTTGTATTTATATCAGCAAACATCAGCCTGAAAGTGTCCGCCAGCATTT
TGAAAAACATCTTCCCAATCGAAATATTTTAATCTCGGTGATTACCTTGGGTGAACTACGTTTTGGTGCTGAAAAAAGTC
AAAGCAAAGAAAAAGCATTAAAAGTCATTGATGAGTTTATCTCAATGATTCAAGTAGCCGAATTAGATGAAGATGTTGCG
GATCATTATGCGCAAATACGTCAAGCGCTTTCTTCTAAAGGTCAGATTATTGGATCTAACGATTTATGGCTTGCAGCGCA
TGCCAGAGCAAATAATTGGGTAATGGTCACCAATAATGAAAAAGAGTTTTTACGTGTTGATGGACTGCGTGTGGAGAATT
GGGTGTCGACTCCCTTATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT201521 WP_000650107.1 NZ_CP074120:3774060-3774455 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT201521 NZ_CP098480:3139233-3139463 [Acinetobacter sp. C32I]
ATGTCTACCGCAAAAGTTTTTATGACCGGTCGTAGTCAAGCAATTCGCTTACCGAAAGAGTTTCGATTTGAAGGCACAGA
AGTTGAAATATTTCGCCGTGGCGATGAAGTGATCCTACGTGAAAAACCAATCACTGCAGAACGCTTATTCAATGTATTAG
CACAGATGCCAGATGATTTTTATGCAGAAGAAAGAGTGGATCAACCACCGCAAGAACGAGAAGAGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References