Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2674586..2675181 Replicon chromosome
Accession NZ_CP074112
Organism Idiomarina loihiensis strain SN11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KGF88_RS12840 Protein ID WP_153827326.1
Coordinates 2674858..2675181 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KGF88_RS12835 Protein ID WP_110075591.1
Coordinates 2674586..2674861 (-) Length 92 a.a.

Genomic Context

KGF88_RS12810KGF88_RS12815KGF88_RS12830KGF88_RS12845KGF88_RS12855KGF88_RS12860KGF88_RS12805KGF88_RS12820KGF88_RS12825KGF88_RS12835KGF88_RS12840KGF88_RS12850
Location: 2671015..2671755 (741 bp)
Type: Others
Protein ID: WP_153827322.1
Location: 2671828..2672310 (483 bp)
Type: Others
Protein ID: WP_153827323.1
Location: 2674008..2674589 (582 bp)
Type: Others
Protein ID: WP_153827325.1
Location: 2675443..2676585 (1143 bp)
Type: Others
Protein ID: WP_110077114.1
Location: 2677540..2678088 (549 bp)
Type: Others
Protein ID: WP_153827299.1
Location: 2678130..2679923 (1794 bp)
Type: Others
Protein ID: WP_153827298.1
Location: 2669964..2670686 (723 bp)
Type: Others
Protein ID: WP_257119940.1
Location: 2672297..2673550 (1254 bp)
Type: Others
Protein ID: WP_153827324.1
Location: 2673547..2673852 (306 bp)
Type: Others
Protein ID: WP_110075600.1
Location: 2674586..2674861 (276 bp)
Type: Antitoxin
Protein ID: WP_110075591.1
Location: 2674858..2675181 (324 bp)
Type: Toxin
Protein ID: WP_153827326.1
Location: 2676650..2677426 (777 bp)
Type: Others
Protein ID: WP_153827300.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KGF88_RS12805 (KGF88_12850)2669964..2670686-723WP_257119940.1methyltransferase domain-containing protein-
KGF88_RS12810 (KGF88_12855)2671015..2671755+741WP_153827322.1GPP34 family phosphoprotein-
KGF88_RS12815 (KGF88_12860)2671828..2672310+483WP_153827323.1diguanylate cyclase-
KGF88_RS12820 (KGF88_12865)2672297..2673550-1254WP_153827324.1type II toxin-antitoxin system HipA family toxin-
KGF88_RS12825 (KGF88_12870)2673547..2673852-306WP_110075600.1transcriptional regulator-
KGF88_RS12830 (KGF88_12875)2674008..2674589+582WP_153827325.1SOS response-associated peptidase-
KGF88_RS12835 (KGF88_12880)2674586..2674861-276WP_110075591.1helix-turn-helix transcriptional regulatorAntitoxin
KGF88_RS12840 (KGF88_12885)2674858..2675181-324WP_153827326.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KGF88_RS12845 (KGF88_12890)2675443..2676585+1143WP_110077114.1RNA-guided endonuclease TnpB family protein-
KGF88_RS12850 (KGF88_12895)2676650..2677426-777WP_153827300.1SDR family oxidoreductase-
KGF88_RS12855 (KGF88_12900)2677540..2678088+549WP_153827299.1hypothetical protein-
KGF88_RS12860 (KGF88_12905)2678130..2679923+1794WP_153827298.1HEAT repeat domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2651944..269225140307
-flankIS/Tn--2675443..26765851142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12010.12 Da        Isoelectric Point: 9.6825

>T201472 WP_153827326.1 NZ_CP074112:c2675181-2674858 [Idiomarina loihiensis]
MSWTITFYSGVEEGLLSLPPKIQARMIRLLELMETHGPNLGPPHTKSIGNGLFELRAKAQEGIARGLFCYLDGERICVLS
VFVKKTQKIPQNEIEIARKRLAEVKTS

Download         Length: 324 bp

>T201472 NZ_CP098446:3721993-3722379 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10414.90 Da        Isoelectric Point: 9.0065

>AT201472 WP_110075591.1 NZ_CP074112:c2674861-2674586 [Idiomarina loihiensis]
MNLEQLKKQALKNPEVKAEYDNLEDEFNLIHQLLNMRAQAGLTQEQLAKRMHTSKSNISRLERGNTNPSWATLVKYAQAC
GFELSLMAHKS

Download         Length: 276 bp

>AT201472 NZ_CP098446:3722372-3722692 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References